Relationships of , , and Gene Polymorphisms with Gestational Diabetes Mellitus in a Chinese Population

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2019 Feb 27

PMID 30805369

Citations 10

Authors

Shimin Hu

Shujuan Ma

Xun Li

Zhengwen Tian

Huiling Liang

Junxia Yan

Mengshi Chen

Hongzhuan Tan

Affiliations

Soon will be listed here.

Abstract

Background: Solute carrier family 2 member 4- (SLC2A4-) retinol binding protein-4- (RBP4-) phosphoenolpyruvate carboxykinase 1 (PCK1)/phosphoinositide 3-kinase (PI3K) is an adipocyte derived "signalling pathway" that may contribute to the pathogenesis of type 2 diabetes mellitus (T2DM). We explored whether single nucleotide polymorphisms (SNPs) of these "signalling pathway" genes are associated with gestational diabetes mellitus (GDM).

Methods: Case-control studies were conducted to compare GDM and control groups. A total of 334 cases and 367 controls were recruited. Seventeen candidate SNPs of the pathway were selected. Chi-square tests, logistic regression, and linear regression were used to estimate the relationships of SNPs with GDM risk and oral glucose tolerance test (OGTT), fasting insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) levels. Model-based multifactor dimensionality reduction was used to estimate the adjusted interactions between genes. Regression and interaction analyses were adjusted by maternal age, prepregnancy BMI, and weekly BMI growth. The Bonferroni correction was applied for multiple comparisons.

Results: rs7091052 was significantly associated with GDM risk. rs5435, rs7091052, rs1042531 and rs2236745, and (coding gene of the PI3K P85 subunit) rs34309 were associated with OGTT, fasting insulin, and HOMA-IR levels in the linear regression analysis. The gene-gene interaction analysis showed that, compared with pregnant women with other genotype combinations, women with rs5435 (CC/CT), rs7091052 (CC), rs1042531 (TT/TG) and rs2236745 (TT), and rs34309 (AA) had lower GDM risk.

Conclusion: , , and genes may be involved in the pathogenesis of GDM.

Citing Articles

Assessment of Changes in the Expression of Genes Involved in Insulin Signaling and Glucose Transport in Leukocytes of Women with Gestational Diabetes During Pregnancy and in the Postpartum Period.

Zieleniak A, Zurawska-Klis M, Laszcz K, Bulash K, Pacyga D, Cypryk K Int J Mol Sci. 2024; 25(23).

PMID: 39684804 PMC: 11641716. DOI: 10.3390/ijms252313094.

Longitudinal integrative cell-free DNA analysis in gestational diabetes mellitus.

Tang Z, Wang S, Li X, Hu C, Zhai Q, Wang J Cell Rep Med. 2024; 5(8):101660.

PMID: 39059385 PMC: 11384941. DOI: 10.1016/j.xcrm.2024.101660.

Genetic and Epigenetic Factors in Gestational Diabetes Mellitus Pathology.

Ustianowski L, Udzik J, Szostak J, Goracy A, Ustianowska K, Pawlik A Int J Mol Sci. 2023; 24(23).

PMID: 38068941 PMC: 10706782. DOI: 10.3390/ijms242316619.

Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review.

Bairqdar A, Ivanoshchuk D, Shakhtshneider E J Pers Med. 2023; 13(3).

PMID: 36983642 PMC: 10056771. DOI: 10.3390/jpm13030460.

Current Studies on Molecular Mechanisms of Insulin Resistance.

Pei J, Wang B, Wang D J Diabetes Res. 2023; 2022:1863429.

PMID: 36589630 PMC: 9803571. DOI: 10.1155/2022/1863429.

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