Aperture Phase Modulation with Adaptive Optics: a Novel Approach for Speckle Reduction and Structure Extraction in Optical Coherence Tomography

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2019 Feb 26

PMID 30800499

Citations 11

Authors

Pengfei Zhang

Suman K Manna

Eric B Miller

Yifan Jian

Ratheesh K Meleppat

Marinko V Sarunic

Edward N Pugh Jr

Robert J Zawadzki

Affiliations

Soon will be listed here.

Abstract

Speckle is an inevitable consequence of the use of coherent light in imaging and acts as noise that corrupts image formation in most applications. Optical coherence tomographic imaging, as a technique employing coherence time gating, suffers from speckle. We present here a novel method of suppressing speckle noise intrinsically compatible with adaptive optics (AO) for confocal coherent imaging: modulation of the phase in the system pupil aperture with a segmented deformable mirror (DM) to introduce minor perturbations in the point spread function. This approach creates uncorrelated speckle patterns in a series of images, enabling averaging to suppress speckle noise while maintaining structural detail. A method is presented that efficiently determines the optimal range of modulation of DM segments relative to their AO-optimized position so that speckle noise is reduced while image resolution and signal strength are preserved. The method is active and independent of sample properties. Its effectiveness and efficiency are quantified and demonstrated by both non-biological and biological applications.

Citing Articles

Revealing speckle obscured living human retinal cells with artificial intelligence assisted adaptive optics optical coherence tomography.

Das V, Zhang F, Bower A, Li J, Liu T, Aguilera N Commun Med (Lond). 2024; 4(1):68.

PMID: 38600290 PMC: 11006674. DOI: 10.1038/s43856-024-00483-1.

Visible-Light Optical Coherence Tomography Fibergraphy of the Tree Shrew Retinal Ganglion Cell Axon Bundles.

Miller D, Grannonico M, Liu M, Savier E, McHaney K, Erisir A IEEE Trans Med Imaging. 2024; 43(8):2769-2777.

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Adaptive optics scanning laser ophthalmoscopy and optical coherence tomography (AO-SLO-OCT) system for mouse retina imaging.

Zhang P, Wahl D, Mocci J, Miller E, Bonora S, Sarunic M Biomed Opt Express. 2023; 14(1):299-314.

PMID: 36698677 PMC: 9841993. DOI: 10.1364/BOE.473447.

Non-Local Mean Denoising Algorithm Based on Fractional Compact Finite Difference Scheme Effectively Reduces Speckle Noise in Optical Coherence Tomography Images.

Chen H, Gao J Micromachines (Basel). 2022; 13(12).

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Spatio-temporal optical coherence tomography provides full thickness imaging of the chorioretinal complex.

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