Interstitial Magnetic Thermotherapy Dosimetry Based on Shear Wave Magnetomotive Optical Coherence Elastography

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2019 Feb 26

PMID 30800498

Citations 6

Authors

Pin-Chieh Huang

Eric J Chaney

Rishyashring R Iyer

Darold R Spillman Jr

Boris Odintsov

Nahil A Sobh

Stephen A Boppart

Affiliations

Soon will be listed here.

Abstract

While magnetic thermoseeds are often utilized in interstitial magnetic thermotherapy (iMT) to enable localized tumor ablation, we propose to extend their use as the perturbative source in magnetomotive optical coherence elastography (MM-OCE) so that the heat-induced elasticity alterations can be 'theranostically' probed. MM-OCE measurements were found to agree with indentation results. Tissue stiffening was visualized on iMT-treated porcine liver and canine soft tissue sarcoma specimens, where histology confirmed thermal damages. Additionally, the elasticity was found to increase exponentially and linearly with the conventional thermal dosage metrics and the deposited thermal energy, respectively. Collectively, a physiologically-meaningful, MM-OCE-based iMT dosimetry is feasible.

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