Small G Protein Signalling Modulator 2 (SGSM2) is Involved in Oestrogen Receptor-positive Breast Cancer Metastasis Through Enhancement of Migratory Cell Adhesion Via Interaction with E-cadherin

Overview

Journal Cell Adh Migr

Specialty Cell Biology

Date 2019 Feb 13

PMID 30744493

Citations 7

Authors

Juo-Han Lin

Wen-Jui Lee

Han-Chung Wu

Chih-Hsiung Wu

Li-Ching Chen

Chi-Cheng Huang

Hang-Lung Chang

Tzu-Chun Cheng

Hui-Wen Chang

Chi-Tang Ho

Shih-Hsin Tu

Yuan-Soon Ho

Affiliations

Soon will be listed here.

Abstract

The function of small G protein signalling modulators (SGSM1/2/3) in cancer remains unknown. Our findings demonstrated that SGSM2 is a plasma membrane protein that strongly interacted with E-cadherin/β-catenin. SGSM2 downregulation enhanced the phosphorylation of focal adhesion kinase (FAK; Y576/577), decreased the expression of epithelial markers such as E-cadherin, β-catenin, and Paxillin, and increased the expression of Snail and Twist-1, which reduced cell adhesion and promoted cancer cell migration. Oestrogen and fibronectin treatment was found to promote the colocalization of SGSM2 at the leading edge with phospho-FAK (Y397). The BioGRID database showed that SGSM2 potentially interacts with cytoskeleton remodelling and cell-cell junction proteins. These evidences suggest that SGSM2 plays a role in modulating cell adhesion and cytoskeleton dynamics during cancer migration.

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