Human and Disease Models to Study Food Allergy

Overview

Journal Asia Pac Allergy

Publisher Wolters Kluwer

Date 2019 Feb 12

PMID 30740352

Citations 5

Authors

Lisa Hung

Helena Obernolte

Katherina Sewald

Thomas Eiwegger

Affiliations

Soon will be listed here.

Abstract

Food allergy is a growing global public health concern. As treatment strategies are currently limited to allergen avoidance and emergency interventions, there is an increasing demand for appropriate models of food allergy for the development of new therapeutics. Many models of food allergy rely heavily on the use of animals, and while useful, many are unable to accurately reflect the human system. In order to bridge the gap between animal models and clinical trials with human patients, human models of food allergy are of great importance. This review will summarize the commonly used human and models of food allergy and highlight their advantages and limitations regarding how accurately they represent the human system. We will cover biopsy-based systems, precision cut organ slices, and coculture systems as well as organoids and organ-on-a-chip. The availability of appropriate experimental models will allow us to move forward in the field of food allergy research, to search for effective treatment options and to further explore the cause and progression of this disorder.

Citing Articles

Research gaps and future needs for allergen prediction in food safety.

Fernandez A, Danisman E, Taheri Boroujerdi M, Kazemi S, Moreno F, Epstein M Front Allergy. 2024; 5:1297547.

PMID: 38440401 PMC: 10911423. DOI: 10.3389/falgy.2024.1297547.

Precision cut intestinal slices, a novel model of acute food allergic reactions.

Hung L, Celik A, Yin X, Yu K, Berenjy A, Kothari A Allergy. 2022; 78(2):500-511.

PMID: 36377289 PMC: 10098956. DOI: 10.1111/all.15579.

Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma.

Breiteneder H, Peng Y, Agache I, Diamant Z, Eiwegger T, Fokkens W Allergy. 2020; 75(12):3039-3068.

PMID: 32893900 PMC: 7756301. DOI: 10.1111/all.14582.

Specific Polyunsaturated Fatty Acids Can Modulate Human moDC2s and Subsequent Th2 Cytokine Release.

Hoppenbrouwers T, Fogliano V, Garssen J, Pellegrini N, Willemsen L, Wichers H Front Immunol. 2020; 11:748.

PMID: 32431702 PMC: 7212991. DOI: 10.3389/fimmu.2020.00748.

Innovation in .

Chang Y Asia Pac Allergy. 2019; 9(1):e10.

PMID: 30740358 PMC: 6365654. DOI: 10.5415/apallergy.2019.9.e10.

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