Helena Obernolte
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Explore the profile of Helena Obernolte including associated specialties, affiliations and a list of published articles.
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16
Citations
144
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Recent Articles
1.
Diesendorf V, La Rocca V, Teutsch M, Alattar H, Obernolte H, Kenst K, et al.
Cells
. 2025 Mar;
14(5).
PMID: 40072063
Cellular metabolism must adapt rapidly to environmental alterations and adjust nutrient uptake. Low glucose availability activates the AMP-dependent kinase (AMPK) pathway. We demonstrate that activation of AMPK or the downstream...
2.
Barlang L, Deimel I, Mohl B, Blaurock C, Balkema-Buschmann A, Weinbender K, et al.
Eur J Pharm Sci
. 2024 Mar;
196:106744.
PMID: 38471595
The use of natural pulmonary surfactants (PS) as a drug delivery vehicle for biologics is a more recent therapeutic modality. Herein, we tested different contents of PS regarding their physicochemical...
3.
Low K, Moller R, Stegmann C, Becker M, Rehburg L, Obernolte H, et al.
J Med Virol
. 2023 Nov;
95(11):e29211.
PMID: 37975336
The emerging viruses SARS-CoV-2 and arenaviruses cause severe respiratory and hemorrhagic diseases, respectively. The production of infectious particles of both viruses and virus spread in tissues requires cleavage of surface...
4.
Diesendorf V, Roll V, Geiger N, Fahr S, Obernolte H, Sewald K, et al.
Front Cell Infect Microbiol
. 2023 Aug;
13:1100028.
PMID: 37637460
Recently, Tummino et al. reported that 34 compounds, including Chloroquine and Fluoxetine, inhibit SARS-CoV-2 replication by inducing phospholipidosis, although Chloroquine failed to suppress viral replication in Calu-3 cells and patients....
5.
Geiger N, Diesendorf V, Roll V, Konig E, Obernolte H, Sewald K, et al.
Int J Mol Sci
. 2023 Feb;
24(4).
PMID: 36835380
Recently, we have described novel pyridyl indole esters and peptidomimetics as potent inhibitors of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) main protease. Here, we analysed the impact...
6.
Hung L, Celik A, Yin X, Yu K, Berenjy A, Kothari A, et al.
Allergy
. 2022 Nov;
78(2):500-511.
PMID: 36377289
Background: Food allergy affects up to 10% of the pediatric population. Despite ongoing efforts, treatment options remain limited. Novel models of food allergy are needed to study response patterns downstream...
7.
Geiger N, Konig E, Oberwinkler H, Roll V, Diesendorf V, Fahr S, et al.
Vaccines (Basel)
. 2022 Oct;
10(10).
PMID: 36298484
Aspirin, with its active compound acetylsalicylic acid (ASA), shows antiviral activity against rhino- and influenza viruses at high concentrations. We sought to investigate whether ASA and its metabolite salicylic acid...
8.
Obernolte H, Niehof M, Braubach P, Fieguth H, Jonigk D, Pfennig O, et al.
Cell Tissue Res
. 2021 Nov;
387(2):249-260.
PMID: 34820703
Chronic obstructive pulmonary disease (COPD) is a complex chronic respiratory disorder often caused by cigarette smoke. Cigarette smoke contains hundreds of toxic substances. In our study, we wanted to identify...
9.
Wronski S, Beinke S, Obernolte H, Belyaev N, Saunders K, Lennon M, et al.
Am J Respir Cell Mol Biol
. 2021 Jun;
65(5):544-554.
PMID: 34181859
Human rhinovirus (RV) is a major risk factor for chronic obstructive pulmonary disease (COPD) and asthma exacerbations. The exploration of RV pathogenesis has been hampered by a lack of disease-relevant...
10.
Habener A, Happle C, Grychtol R, Skuljec J, Busse M, Daluge K, et al.
J Allergy Clin Immunol
. 2020 Nov;
147(6):2281-2294.e7.
PMID: 33249168
Background: Asthma is a widespread, multifactorial chronic airway disease. The influence of regulatory B cells on airway hyperreactivity (AHR) and remodeling in asthma is poorly understood. Objective: Our aim was...