CD23: an Overlooked Regulator of Allergic Disease

Overview

Journal Curr Allergy Asthma Rep

Specialties Allergy & Immunology
Pulmonary Medicine

Date 2007 Aug 19

PMID 17697638

Citations 42

Authors

Daniel H Conrad

Jill W Ford

Jamie L Sturgill

David R Gibb

Affiliations

Soon will be listed here.

Abstract

Given the importance of immunoglobulin (Ig) E in mediating type I hypersensitivity, inhibiting IgE production would be a general way of controlling allergic disease. The low-affinity IgE receptor (FceRII or CD23) has long been proposed to be a natural regulator of IgE synthesis. In vivo research supporting this concept includes the observation that mice lacking CD23 have increased IgE production whereas mice overexpressing CD23 show strongly suppressed IgE responses. In addition, the finding that mice injected with monoclonal antibody directed against the coiled-coil stalk of CD23 have enhanced soluble CD23 release and increased IgE production demonstrates that full-length, trimeric CD23 is responsible for initiating an IgE inhibitory signal. The recent identification of ADAM10 (a disintegrin and metalloprotease) as the CD23 metalloprotease provides an alternative approach for designing therapies to combat allergic disease. Current data suggest that stabilizing cell-surface CD23 would be a natural means to decrease IgE synthesis and thus control type I hypersensitivity.

Citing Articles

A Comparison of Natural and Therapeutic Anti-IgE Antibodies.

Vogel M, Engeroff P Antibodies (Basel). 2024; 13(3).

PMID: 39051334 PMC: 11270207. DOI: 10.3390/antib13030058.

On the complexity of IgE: The role of structural flexibility and glycosylation for binding its receptors.

Plattner K, Bachmann M, Vogel M Front Allergy. 2023; 4:1117611.

PMID: 37056355 PMC: 10089267. DOI: 10.3389/falgy.2023.1117611.

IgE-neutralizing UB-221 mAb, distinct from omalizumab and ligelizumab, exhibits CD23-mediated IgE downregulation and relieves urticaria symptoms.

Kuo B, Li C, Chen J, Shiung Y, Chu C, Lee C J Clin Invest. 2022; 132(15).

PMID: 35912861 PMC: 9337824. DOI: 10.1172/JCI157765.

Lack of Ecto-5'-Nucleotidase Protects Sensitized Mice against Allergen Challenge.

Caiazzo E, Cerqua I, Turiello R, Riemma M, De Palma G, Ialenti A Biomolecules. 2022; 12(5).

PMID: 35625624 PMC: 9139122. DOI: 10.3390/biom12050697.

Function of Protein S-Palmitoylation in Immunity and Immune-Related Diseases.

Zhang Y, Qin Z, Sun W, Chu F, Zhou F Front Immunol. 2021; 12:661202.

PMID: 34557182 PMC: 8453015. DOI: 10.3389/fimmu.2021.661202.

References

Lewis G, Rapsomaniki E, Bouriez T, Crockford T, Ferry H, Rigby R . Hyper IgE in New Zealand black mice due to a dominant-negative CD23 mutation. Immunogenetics. 2004; 56(8):564-71. DOI: 10.1007/s00251-004-0728-4. View

Cernadas M, De Sanctis G, Krinzman S, Mark D, Donovan C, Listman J . CD23 and allergic pulmonary inflammation: potential role as an inhibitor. Am J Respir Cell Mol Biol. 1998; 20(1):1-8. DOI: 10.1165/ajrcmb.20.1.3299. View

Hibbert R, Teriete P, Grundy G, Beavil R, Reljic R, Holers V . The structure of human CD23 and its interactions with IgE and CD21. J Exp Med. 2005; 202(6):751-60. PMC: 2212946. DOI: 10.1084/jem.20050811. View

Yu P, Kosco-Vilbois M, Richards M, Kohler G, Lamers M . Negative feedback regulation of IgE synthesis by murine CD23. Nature. 1994; 369(6483):753-6. DOI: 10.1038/369753a0. View

Kelly A, Chen B, Woodward E, Conrad D . Production of a chimeric form of CD23 that is oligomeric and blocks IgE binding to the Fc epsilonRI. J Immunol. 1998; 161(12):6696-704. View

Haczku A, Takeda K, Hamelmann E, Loader J, Joetham A, Redai I . CD23 exhibits negative regulatory effects on allergic sensitization and airway hyperresponsiveness. Am J Respir Crit Care Med. 2000; 161(3 Pt 1):952-60. DOI: 10.1164/ajrccm.161.3.9905046. View

Kilmon M, Ghirlando R, Strub M, Beavil R, Gould H, Conrad D . Regulation of IgE production requires oligomerization of CD23. J Immunol. 2001; 167(6):3139-45. DOI: 10.4049/jimmunol.167.6.3139. View

Poole J, Meng J, Reff M, Spellman M, Rosenwasser L . Anti-CD23 monoclonal antibody, lumiliximab, inhibited allergen-induced responses in antigen-presenting cells and T cells from atopic subjects. J Allergy Clin Immunol. 2005; 116(4):780-8. DOI: 10.1016/j.jaci.2005.07.007. View

Haczku A, Takeda K, Hamelmann E, Oshiba A, Loader J, Joetham A . CD23 deficient mice develop allergic airway hyperresponsiveness following sensitization with ovalbumin. Am J Respir Crit Care Med. 1997; 156(6):1945-55. DOI: 10.1164/ajrccm.156.6.9701087. View

10.

Blobel C . ADAMs: key components in EGFR signalling and development. Nat Rev Mol Cell Biol. 2005; 6(1):32-43. DOI: 10.1038/nrm1548. View

11.

Weskamp G, Ford J, Sturgill J, Martin S, Docherty A, Swendeman S . ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23. Nat Immunol. 2006; 7(12):1293-8. DOI: 10.1038/ni1399. View

12.

Gould H, Sutton B, Beavil A, Beavil R, McCloskey N, Coker H . The biology of IGE and the basis of allergic disease. Annu Rev Immunol. 2002; 21:579-628. DOI: 10.1146/annurev.immunol.21.120601.141103. View

13.

Pongratz G, McAlees J, Conrad D, Erbe R, Haas K, Sanders V . The level of IgE produced by a B cell is regulated by norepinephrine in a p38 MAPK- and CD23-dependent manner. J Immunol. 2006; 177(5):2926-38. DOI: 10.4049/jimmunol.177.5.2926. View

14.

Dierks S, BARTLETT W, Edmeades R, Gould H, Rao M, Conrad D . The oligomeric nature of the murine Fc epsilon RII/CD23. Implications for function. J Immunol. 1993; 150(6):2372-82. View

15.

Flores-Romo L, Shields J, Humbert Y, Graber P, Aubry J, Gauchat J . Inhibition of an in vivo antigen-specific IgE response by antibodies to CD23. Science. 1993; 261(5124):1038-41. DOI: 10.1126/science.8351517. View

16.

Helm S, Wu J, Kilmon M, Fakher M, Basalp A, Tew J . Suppression of IgE responses in CD23-transgenic animals is due to expression of CD23 on nonlymphoid cells. J Immunol. 2001; 166(8):4863-9. DOI: 10.4049/jimmunol.166.8.4863. View

17.

Yu L, Montagnac G, Yang P, Conrad D, Benmerah A, Perdue M . Intestinal epithelial CD23 mediates enhanced antigen transport in allergy: evidence for novel splice forms. Am J Physiol Gastrointest Liver Physiol. 2003; 285(1):G223-34. DOI: 10.1152/ajpgi.00445.2002. View

18.

Wakai M, Pasley P, Sthoeger Z, Posnett D, Brooks R, Hashimoto S . Anti-CD23 monoclonal antibodies: comparisons of epitope specificities and modulating capacities for IgE binding and production. Hybridoma. 1993; 12(1):25-43. DOI: 10.1089/hyb.1993.12.25. View

19.

Sukumar S, Conrad D, Szakal A, Tew J . Differential T cell-mediated regulation of CD23 (Fc epsilonRII) in B cells and follicular dendritic cells. J Immunol. 2006; 176(8):4811-7. DOI: 10.4049/jimmunol.176.8.4811. View

20.

Payet M, Woodward E, Conrad D . Humoral response suppression observed with CD23 transgenics. J Immunol. 1999; 163(1):217-23. View