Polydopamine-Based Surface Modification of ZnO Nanoparticles on Sericin/Polyvinyl Alcohol Composite Film for Antibacterial Application

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2019 Feb 2

PMID 30704137

Citations 11

Authors

Lisha Ai

Yejing Wang

Gang Tao

Ping Zhao

Ahmad Umar

Peng Wang

Huawei He

Affiliations

Soon will be listed here.

Abstract

Silk sericin (SS) is a type of natural macromolecular protein with excellent hydrophilicity, biocompatibility and biodegradability, but also has very poor mechanical properties. To develop sericin-based wound dressings, we utilized polyvinyl alcohol (PVA) to reinforce the mechanical property of sericin by blending PVA and sericin, then modified zinc oxide nanoparticles (ZnO NPs) on SS/PVA film with the assistance of polydopamine (PDA) to endow SS/PVA film with antibacterial activity. Scanning electron microscopy, energy dispersive spectroscopy and X-ray powder diffraction demonstrated ZnO NPs were well grafted on PDA-SS/PVA film. Fourier transform infrared spectra suggested PDA coating and ZnONPs modification did not alter the structure of sericin and PVA. Water contact angle and swelling tests indicated the excellent hydrophilicity and swellability of ZnO NPs-PDA-SS/PVA composite film. Mass loss analysis showed ZnO NPs-PDA-SS/PVA film had excellent stability. The mechanical performance test suggested the improved tensile strength and elongation at break could meet the requirement of ZnO NPs-PDA-SS/PVA film in biomaterial applications. The antibacterial assay suggested the prepared ZnO NPs-PDA-SS/PVA composite film had a degree of antimicrobial activity against and . The excellent hydrophilicity, swellability, stability, mechanical property and antibacterial activity greatly promote the possibility of ZnO NPs-PDA-SS/PVA composite film in antibacterial biomaterials application.

Citing Articles

Evaluation of Sericin/Polyvinyl Alcohol Mixtures for Developing Porous and Stable Structures.

Arango M, Vasquez Vasquez L, Parra A, Rueda-Mira S, Jaramillo-Quiceno N, Cerisuelo J Biomimetics (Basel). 2025; 10(1).

PMID: 39851744 PMC: 11762549. DOI: 10.3390/biomimetics10010027.

Polydopamine-Based Biomaterials in Orthopedic Therapeutics: Properties, Applications, and Future Perspectives.

Zhang M, Mi M, Hu Z, Li L, Chen Z, Gao X Drug Des Devel Ther. 2024; 18:3765-3790.

PMID: 39219693 PMC: 11363944. DOI: 10.2147/DDDT.S473007.

Silk Sericin and Its Composite Materials with Antibacterial Properties to Enhance Wound Healing: A Review.

Wang S, Zhuo J, Fang S, Xu W, Yu Q Biomolecules. 2024; 14(6).

PMID: 38927126 PMC: 11201629. DOI: 10.3390/biom14060723.

Current status and progress in research on dressing management for diabetic foot ulcer.

Jiang P, Li Q, Luo Y, Luo F, Che Q, Lu Z Front Endocrinol (Lausanne). 2023; 14:1221705.

PMID: 37664860 PMC: 10470649. DOI: 10.3389/fendo.2023.1221705.

The CuO and AgO co-modified ZnO nanocomposites for promoting wound healing in infection.

Ye L, He X, Obeng E, Wang D, Zheng D, Shen T Mater Today Bio. 2023; 18:100552.

PMID: 36819756 PMC: 9936377. DOI: 10.1016/j.mtbio.2023.100552.

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