Sericin Based Nanoformulations: a Comprehensive Review on Molecular Mechanisms of Interaction with Organisms to Biological Applications

Overview

Journal J Nanobiotechnology

Publisher Biomed Central

Specialty Biotechnology

Date 2021 Jan 23

PMID 33482828

Citations 32

Authors

Gitishree Das

Han-Seung Shin

Estefania V Ramos Campos

Leonardo Fernandes Fraceto

Maria Del Pilar Rodriguez-Torres

Kelli Cristina Freitas Mariano

Daniele Ribeiro de Araujo

Fabian Fernandez-Luqueno

Renato Grillo

Jayanta Kumar Patra

Affiliations

Soon will be listed here.

Abstract

Background: The advances in products based on nanotechnology have directed extensive research on low-cost, biologically compatible, and easily degradable materials.

Main Body: Sericin (SER) is a protein mainly composed of glycine, serine, aspartic acid, and threonine amino acids removed from the silkworm cocoon (particularly Bombyx mori and other species). SER is a biocompatible material with economic viability, which can be easily functionalized due to its potential crosslink reactions. Also, SER has inherent biological properties, which makes possible its use as a component of pharmaceutical formulations with several biomedical applications, such as anti-tumor, antimicrobials, antioxidants and as scaffolds for tissue repair as well as participating in molecular mechanisms attributed to the regulation of transcription factors, reduction of inflammatory signaling molecules, stimulation of apoptosis, migration, and proliferation of mesenchymal cells.

Conclusion: In this review, the recent innovations on SER-based nano-medicines (nanoparticles, micelles, films, hydrogels, and their hybrid systems) and their contributions for non-conventional therapies are discussed considering different molecular mechanisms for promoting their therapeutic applications.

Citing Articles

Innovative Processing and Sterilization Techniques to Unlock the Potential of Silk Sericin for Biomedical Applications.

Veiga A, Ramirez-Jimenez R, Santos-Rosales V, Garcia-Gonzalez C, Aguilar M, Rojo L Gels. 2025; 11(2).

PMID: 39996657 PMC: 11854797. DOI: 10.3390/gels11020114.

Evaluation of Sericin/Polyvinyl Alcohol Mixtures for Developing Porous and Stable Structures.

Arango M, Vasquez Vasquez L, Parra A, Rueda-Mira S, Jaramillo-Quiceno N, Cerisuelo J Biomimetics (Basel). 2025; 10(1).

PMID: 39851744 PMC: 11762549. DOI: 10.3390/biomimetics10010027.

Synthesis and characterization of selenium nanoparticles stabilized with oxyethylated alkylphenol (neonol) for potential modification of fabric materials.

Rekhman Z, Blinov A, Gvozdenko A, Golik A, Nagdalian A, Blinova A PLoS One. 2024; 19(11):e0314208.

PMID: 39591417 PMC: 11593756. DOI: 10.1371/journal.pone.0314208.

Sericin Protein: Structure, Properties, and Applications.

Aad R, Dragojlov I, Vesentini S J Funct Biomater. 2024; 15(11).

PMID: 39590526 PMC: 11595228. DOI: 10.3390/jfb15110322.

Repurposing of sericin combined with dactolisib or vitamin D to combat non-small lung cancer cells through computational and biological investigations.

Helmy M, Youssef M, Yamari I, Amr A, Moussa F, El Wakil A Sci Rep. 2024; 14(1):27034.

PMID: 39505930 PMC: 11541877. DOI: 10.1038/s41598-024-76947-0.

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