Nucleus Accumbens Modulation in Reward and Aversion

Overview

Journal Cold Spring Harb Symp Quant Biol

Specialty Biology

Date 2019 Jan 25

PMID 30674650

Citations 45

Authors

Anna M Klawonn

Robert C Malenka

Affiliations

Soon will be listed here.

Abstract

The nucleus accumbens (NAc) is a key node of the brain's circuitry that is responsible for translating motivation into action. It has been implicated in playing critical roles in virtually all forms of adaptive and pathological motivated behaviors. It is subject to modulation by a broad array of inputs that influence NAc activity in complex ways that are still poorly understood. Here, we briefly review current knowledge about the behavioral consequences of NAc modulation, focusing on recent studies that use novel techniques developed and implemented over the last decade.

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References

ODonnell P, Greene J, Pabello N, Lewis B, Grace A . Modulation of cell firing in the nucleus accumbens. Ann N Y Acad Sci. 1999; 877:157-75. DOI: 10.1111/j.1749-6632.1999.tb09267.x. View

Haber S, Fudge J, McFarland N . Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum. J Neurosci. 2000; 20(6):2369-82. PMC: 6772499. View

Nicola S, Surmeier J, Malenka R . Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens. Annu Rev Neurosci. 2000; 23:185-215. DOI: 10.1146/annurev.neuro.23.1.185. View

Di Chiara G . Nucleus accumbens shell and core dopamine: differential role in behavior and addiction. Behav Brain Res. 2002; 137(1-2):75-114. DOI: 10.1016/s0166-4328(02)00286-3. View

DAHLSTROEM A, Fuxe K . EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS. Acta Physiol Scand Suppl. 1964; :SUPPL 232:1-55. View

DAHLSTROEM A, Fuxe K . EVIDENCE FOR THE EXISTENCE OF MONOAMINE NEURONS IN THE CENTRAL NERVOUS SYSTEM. II. EXPERIMENTALLY INDUCED CHANGES IN THE INTRANEURONAL AMINE LEVELS OF BULBOSPINAL NEURON SYSTEMS. Acta Physiol Scand Suppl. 1965; :SUPPL 247:1-36. View

Zahm D, Brog J . On the significance of subterritories in the "accumbens" part of the rat ventral striatum. Neuroscience. 1992; 50(4):751-67. DOI: 10.1016/0306-4522(92)90202-d. View

Gerfen C . The neostriatal mosaic: multiple levels of compartmental organization in the basal ganglia. Annu Rev Neurosci. 1992; 15:285-320. DOI: 10.1146/annurev.ne.15.030192.001441. View

Nestler E . Is there a common molecular pathway for addiction?. Nat Neurosci. 2005; 8(11):1445-9. DOI: 10.1038/nn1578. View

10.

Volkow N, Wang G, Telang F, Fowler J, Logan J, Childress A . Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction. J Neurosci. 2006; 26(24):6583-8. PMC: 6674019. DOI: 10.1523/JNEUROSCI.1544-06.2006. View

11.

Nicola S . The nucleus accumbens as part of a basal ganglia action selection circuit. Psychopharmacology (Berl). 2006; 191(3):521-50. DOI: 10.1007/s00213-006-0510-4. View

12.

Ikemoto S . Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. Brain Res Rev. 2007; 56(1):27-78. PMC: 2134972. DOI: 10.1016/j.brainresrev.2007.05.004. View

13.

Day J, Roitman M, Wightman R, Carelli R . Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens. Nat Neurosci. 2007; 10(8):1020-8. DOI: 10.1038/nn1923. View

14.

Krishnan V, Han M, Graham D, Berton O, Renthal W, Russo S . Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell. 2007; 131(2):391-404. DOI: 10.1016/j.cell.2007.09.018. View

15.

Lammel S, Hetzel A, Hackel O, Jones I, Liss B, Roeper J . Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system. Neuron. 2008; 57(5):760-73. DOI: 10.1016/j.neuron.2008.01.022. View

16.

Reynolds S, Berridge K . Emotional environments retune the valence of appetitive versus fearful functions in nucleus accumbens. Nat Neurosci. 2008; 11(4):423-5. PMC: 2717027. DOI: 10.1038/nn2061. View

17.

Roitman M, Wheeler R, Wightman R, Carelli R . Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli. Nat Neurosci. 2008; 11(12):1376-7. PMC: 3171188. DOI: 10.1038/nn.2219. View

18.

Kreitzer A, Malenka R . Striatal plasticity and basal ganglia circuit function. Neuron. 2008; 60(4):543-54. PMC: 2724179. DOI: 10.1016/j.neuron.2008.11.005. View

19.

Wise R . Dopamine and reward: the anhedonia hypothesis 30 years on. Neurotox Res. 2008; 14(2-3):169-83. PMC: 3155128. DOI: 10.1007/BF03033808. View

20.

Tsai H, Zhang F, Adamantidis A, Stuber G, Bonci A, De Lecea L . Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. Science. 2009; 324(5930):1080-4. PMC: 5262197. DOI: 10.1126/science.1168878. View