Loss of MiR-210 Leads to Progressive Retinal Degeneration in

Overview

Journal Life Sci Alliance

Specialties Biochemistry
Biology
Cell Biology
Molecular Biology

Date 2019 Jan 24

PMID 30670478

Citations 12

Authors

Carina M Weigelt

Oliver Hahn

Katharina Arlt

Matthias Gruhn

Annika J Jahn

Jacqueline Esser

Jennifer A Werner

Corinna Klein

Ansgar Buschges

Sebastian Gronke

Linda Partridge

Affiliations

Soon will be listed here.

Abstract

miRNAs are small, non-coding RNAs that regulate gene expression post-transcriptionally. We used small RNA sequencing to identify tissue-specific miRNAs in the adult brain, thorax, gut, and fat body of One of the most brain-specific miRNAs that we identified was miR-210, an evolutionarily highly conserved miRNA implicated in the regulation of hypoxia in mammals. In , we show that miR-210 is specifically expressed in sensory organs, including photoreceptors. miR-210 knockout mutants are not sensitive toward hypoxia but show progressive degradation of photoreceptor cells, accompanied by decreased photoreceptor potential, demonstrating an important function of miR-210 in photoreceptor maintenance and survival.

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