Extracellular Vesicle Quantification and Characterization: Common Methods and Emerging Approaches

Overview

Journal Bioengineering (Basel)

Date 2019 Jan 19

PMID 30654439

Citations 162

Authors

Thomas A Hartjes

Serhii Mytnyk

Guido W Jenster

Volkert van Steijn

Martin E van Royen

Affiliations

Soon will be listed here.

Abstract

Extracellular vesicles (EVs) are a family of small membrane vesicles that carry information about cells by which they are secreted. Growing interest in the role of EVs in intercellular communication, but also in using their diagnostic, prognostic and therapeutic potential in (bio) medical applications, demands for accurate assessment of their biochemical and physical properties. In this review, we provide an overview of available technologies for EV analysis by describing their working principles, assessing their utility in EV research and summarising their potential and limitations. To emphasise the innovations in EV analysis, we also highlight the unique possibilities of emerging technologies with high potential for further development.

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