The Kindlin Family of Adapter Proteins

Overview

Journal Circ Res

Specialty Cardiology & Vascular Diseases

Date 2019 Jan 18

PMID 30653443

Citations 20

Authors

Edward F Plow

Jun Qin

Affiliations

Soon will be listed here.

Citing Articles

Role of Kindlin 2 in prostate cancer.

Bialkowska K, El Khalki L, Rana P, Wang W, Lindner D, Parker Y Sci Rep. 2024; 14(1):19809.

PMID: 39191802 PMC: 11349918. DOI: 10.1038/s41598-024-70202-2.

Pan-cancer analyses suggest kindlin-associated global mechanochemical alterations.

Chowdhury D, Mistry A, Maity D, Bhatia R, Priyadarshi S, Wadan S Commun Biol. 2024; 7(1):372.

PMID: 38548811 PMC: 10978987. DOI: 10.1038/s42003-024-06044-5.

Single-cell and bulk transcriptional profiling of mouse ovaries reveals novel genes and pathways associated with DNA damage response in oocytes.

Mills M, Emori C, Kumar P, Boucher Z, George J, Bolcun-Filas E bioRxiv. 2024; .

PMID: 38352597 PMC: 10862846. DOI: 10.1101/2024.02.02.578648.

FERM domain-containing proteins are active components of the cell nucleus.

Borkuti P, Kristo I, Szabo A, Kovacs Z, Vilmos P Life Sci Alliance. 2024; 7(4).

PMID: 38296350 PMC: 10830384. DOI: 10.26508/lsa.202302489.

Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis.

Wu X, Lai Y, Chen S, Zhou C, Tao C, Fu X Nat Aging. 2023; 2(4):332-347.

PMID: 37117739 DOI: 10.1038/s43587-021-00165-w.

References

Plow E, Das M, Bialkowska K, Sossey-Alaoui K . Of Kindlins and Cancer. Discoveries (Craiova). 2016; 4(2). PMC: 4971757. DOI: 10.15190/d.2016.6. View

Humphries J, Chastney M, Askari J, Humphries M . Signal transduction via integrin adhesion complexes. Curr Opin Cell Biol. 2018; 56:14-21. DOI: 10.1016/j.ceb.2018.08.004. View

Ma Y, Qin J, Wu C, Plow E . Kindlin-2 (Mig-2): a co-activator of beta3 integrins. J Cell Biol. 2008; 181(3):439-46. PMC: 2364684. DOI: 10.1083/jcb.200710196. View

Malinin N, Zhang L, Choi J, Ciocea A, Razorenova O, Ma Y . A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans. Nat Med. 2009; 15(3):313-8. PMC: 2857384. DOI: 10.1038/nm.1917. View

Vinogradova O, Velyvis A, Velyviene A, Hu B, Haas T, Plow E . A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face. Cell. 2002; 110(5):587-97. DOI: 10.1016/s0092-8674(02)00906-6. View

Bachir A, Zareno J, Moissoglu K, Plow E, Gratton E, Horwitz A . Integrin-associated complexes form hierarchically with variable stoichiometry in nascent adhesions. Curr Biol. 2014; 24(16):1845-53. PMC: 4138543. DOI: 10.1016/j.cub.2014.07.011. View

Luo B, Carman C, Springer T . Structural basis of integrin regulation and signaling. Annu Rev Immunol. 2007; 25:619-47. PMC: 1952532. DOI: 10.1146/annurev.immunol.25.022106.141618. View

Theodosiou M, Widmaier M, Bottcher R, Rognoni E, Veelders M, Bharadwaj M . Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin. Elife. 2016; 5:e10130. PMC: 4749545. DOI: 10.7554/eLife.10130. View

Ye F, Petrich B, Anekal P, Lefort C, Kasirer-Friede A, Shattil S . The mechanism of kindlin-mediated activation of integrin αIIbβ3. Curr Biol. 2013; 23(22):2288-2295. PMC: 3912999. DOI: 10.1016/j.cub.2013.09.050. View

10.

Rogalski T, Mullen G, Gilbert M, Williams B, Moerman D . The UNC-112 gene in Caenorhabditis elegans encodes a novel component of cell-matrix adhesion structures required for integrin localization in the muscle cell membrane. J Cell Biol. 2000; 150(1):253-64. PMC: 2185566. DOI: 10.1083/jcb.150.1.253. View

11.

Malinin N, Plow E, Byzova T . Kindlins in FERM adhesion. Blood. 2010; 115(20):4011-7. PMC: 2875095. DOI: 10.1182/blood-2009-10-239269. View

12.

Goksoy E, Ma Y, Wang X, Kong X, Perera D, Plow E . Structural basis for the autoinhibition of talin in regulating integrin activation. Mol Cell. 2008; 31(1):124-33. PMC: 2522368. DOI: 10.1016/j.molcel.2008.06.011. View

13.

Liu J, Das M, Yang J, Ithychanda S, Yakubenko V, Plow E . Structural mechanism of integrin inactivation by filamin. Nat Struct Mol Biol. 2015; 22(5):383-9. PMC: 4424056. DOI: 10.1038/nsmb.2999. View

14.

Li H, Deng Y, Sun K, Yang H, Liu J, Wang M . Structural basis of kindlin-mediated integrin recognition and activation. Proc Natl Acad Sci U S A. 2017; 114(35):9349-9354. PMC: 5584418. DOI: 10.1073/pnas.1703064114. View

15.

Montanez E, Ussar S, Schifferer M, Bosl M, Zent R, Moser M . Kindlin-2 controls bidirectional signaling of integrins. Genes Dev. 2008; 22(10):1325-30. PMC: 2377186. DOI: 10.1101/gad.469408. View