The Cellular Effects of Novel Triazine Nitrogen Mustards in Glioblastoma LBC3, LN-18 and LN-229 Cell Lines

Overview

Journal Invest New Drugs

Publisher Springer

Specialty Oncology

Date 2019 Jan 16

PMID 30645699

Citations 2

Authors

Rafal Kretowski

Danuta Drozdowska

Beata Kolesinska

Zbigniew Kaminski

Justyna Fraczyk

Marzanna Cechowska-Pasko

Affiliations

Soon will be listed here.

Abstract

1,3,5-triazine is an important heterocyclic skeleton for mono, two or three 2-chloroethylamine groups. The study presented here provides novel information on cellular effects of 1,3,5-triazine with mono, two or three 2-chloroethylamine groups in glioblastoma LBC3, LN-18 and LN-229 cell lines. In our study, the most cytotoxic effect was observed in 1,3,5-triazine with three 2-chloroethylamine groups (12f compound). It has been demonstrated that 12f induce time- and dose-dependent cytotoxicity in all investigated glioma cell lines. Apart from that in glioblastoma cells, treated with 12f compound, we noticed strong induction of apoptosis. In conclusion, this research provides novel information concerning cellular effects of apoptosis in LBC3, LN-18 and LN-229 cell lines. Moreover, we suggest that 12f compound may be a candidate for further evaluation as an effective chemotherapeutic agent for human glioblastoma cells.

Citing Articles

Recent Advances in the Biological Activity of s-Triazine Core Compounds.

Maliszewski D, Drozdowska D Pharmaceuticals (Basel). 2022; 15(2).

PMID: 35215333 PMC: 8875733. DOI: 10.3390/ph15020221.

Synthesis and cellular effects of novel 1,3,5-triazine derivatives in DLD and Ht-29 human colon cancer cell lines.

Wrobel A, Kolesinska B, Fraczyk J, Kaminski Z, Tankiewicz-Kwedlo A, Hermanowicz J Invest New Drugs. 2019; 38(4):990-1002.

PMID: 31520321 PMC: 7340680. DOI: 10.1007/s10637-019-00838-9.

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