Danuta Drozdowska
Overview
Explore the profile of Danuta Drozdowska including associated specialties, affiliations and a list of published articles.
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24
Citations
132
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Recent Articles
1.
El-Wakil M, Ghazala R, El-Dershaby H, Drozdowska D, Wrobel-Talalaj A, Parzych C, et al.
J Enzyme Inhib Med Chem
. 2025 Mar;
40(1):2468353.
PMID: 40035286
In light of searching for new breast cancer therapies, DNA-targeted small molecules were rationally designed to simultaneously bind DNA and inhibit human dihydrofolate reductase (DHFR). Fourteen new arylidene-hydrazinyl-1,3-thiazoles () were...
2.
Drozdowska D, Wrobel-Talalaj A, Parzych C, Ratkiewicz A
Biomedicines
. 2024 May;
12(5).
PMID: 38791041
Human dihydrofolate reductase (DHFR) is an essential cellular enzyme, and inhibiting its activity is a promising strategy for cancer therapy. We have chosen the trimethoprim molecule () as a model...
3.
Drozdowska D, Maliszewski D, Wrobel A, Ratkiewicz A, Sienkiewicz M
Int J Mol Sci
. 2023 Oct;
24(19).
PMID: 37834347
The synthesis of eleven new and previously undescribed benzamides was designed. These compounds were specifically projected as potential inhibitors of the enzymes acetylcholinesterase (AChE) and β-secretase (BACE1). N,N'-(1,4-phenylene)bis(3-methoxybenzamide) was most...
4.
Maliszewski D, Demirel R, Wrobel A, Baradyn M, Ratkiewicz A, Drozdowska D
Pharmaceuticals (Basel)
. 2023 Sep;
16(9).
PMID: 37765056
The spectrum of biological properties of s-triazine derivatives is broad and includes anti-microbial, anti-cancer, and anti-neurodegenerative activities, among others. The s-triazine molecule, due to the possibility of substituting three substituents,...
5.
Maliszewski D, Drozdowska D
Pharmaceuticals (Basel)
. 2022 Feb;
15(2).
PMID: 35215333
An effective strategy for successful chemotherapy relies on creating compounds with high selectivity against cancer cells compared to normal cells and relatively low cytotoxicity. One such approach is the discovery...
6.
Maliszewski D, Wrobel A, Kolesinska B, Fraczyk J, Drozdowska D
Molecules
. 2021 Jul;
26(13).
PMID: 34203347
A series of new analogs of nitrogen mustards (-) containing the 1,3,5-triazine ring substituted with dipeptide residue were synthesized and evaluated for the inhibition of both acetylcholinesterase (AChE) and -secretase...
7.
Wrobel A, Baradyn M, Ratkiewicz A, Drozdowska D
Int J Mol Sci
. 2021 Apr;
22(7).
PMID: 33916202
Eighteen previously undescribed trimethoprim (TMP) analogs containing amide bonds () were synthesized and compared with TMP, methotrexate (MTX), and netropsin (NT). These compounds were designed as potential minor groove binding...
8.
Wrobel A, Maliszewski D, Baradyn M, Drozdowska D
Molecules
. 2020 Jan;
25(1).
PMID: 31892256
A new series of trimethoprim (TMP) analogs containing amide bonds (-) have been synthesized. Molecular docking, as well as dihydrofolate reductase (DHFR) inhibition assay were used to confirm their affinity...
9.
Wrobel A, Drozdowska D
Curr Med Chem
. 2019 Oct;
28(5):910-939.
PMID: 31622199
Background: Dihydrofolate reductase (DHFR) has been known for decades as a molecular target for antibacterial, antifungal and anti-malarial treatments. This enzyme is becoming increasingly important in the design of new...
10.
Wrobel A, Arciszewska K, Maliszewski D, Drozdowska D
J Antibiot (Tokyo)
. 2019 Oct;
73(1):5-27.
PMID: 31578455
The development of new mechanisms of resistance among pathogens, the occurrence and transmission of genes responsible for antibiotic insensitivity, as well as cancer diseases have been a serious clinical problem...