Exosome Source Matters: A Comprehensive Review from the Perspective of Diverse Cellular Origins

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2025 Feb 26

PMID 40006514

Authors

Yiru Chen

Weikun Qi

Zhenghao Wang

Feng Niu

Affiliations

Soon will be listed here.

Abstract

Exosomes have emerged as promising therapeutic agents in regenerative medicine. This review introduces a novel cell type-oriented perspective to systematically analyze exosomal properties in regenerative therapies. To our knowledge, this review is the first to comprehensively compare exosomes based on cellular source type, offering unprecedented insights into selecting optimal exosome producers for targeted regenerative applications. Factors beyond cellular origin influencing exosomal therapeutic efficacy, such as donor sites and collection methods, are also explored here. By synthesizing key advances, we propose promising research directions in the end. We aim to accelerate the development of more effective exosome-based regenerative therapies and highlight underexplored directions in this rapidly evolving field.

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