Mesenchymal-epithelial Transition in Development and Reprogramming

Overview

Journal Nat Cell Biol

Specialty Cell Biology

Date 2019 Jan 4

PMID 30602762

Citations 128

Authors

Duanqing Pei

Xiaodong Shu

Ama Gassama-Diagne

Jean Paul Thiery

Affiliations

Soon will be listed here.

Abstract

During organogenesis, epithelial cells can give rise to mesenchymal cells through epithelial-mesenchymal transition. The reverse process, mesenchymal-epithelial transition (MET), can similarly generate epithelial cells. Transitions between epithelial and mesenchymal states are also critical for the induction of pluripotent stem cells from somatic cells. This Review discusses the relatively less characterized process of MET, focusing on the genesis of apicobasal cell polarity and exploring the roles of MET in development and reprogramming.

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