Roles of Grainyhead-like Transcription Factors in Cancer

Overview

Journal Oncogene

Specialties Molecular Biology
Oncology

Date 2017 Jul 18

PMID 28714958

Citations 41

Authors

S M Frisch

J C Farris

P M Pifer

Affiliations

Soon will be listed here.

Abstract

The mammalian homologs of the D. melanogaster Grainyhead gene, Grainyhead-like 1-3 (GRHL1, GRHL2 and GRHL3), are transcription factors implicated in wound healing, tubulogenesis and cancer. Their induced target genes encode diverse epithelial cell adhesion molecules, while mesenchymal genes involved in cell migration and invasion are repressed. Moreover, GRHL2 suppresses the oncogenic epithelial-mesencyhmal transition, thereby acting as a tumor suppressor. Mechanisms, some involving established cancer-related signaling/transcription factor pathways (for example, Wnt, TGF-β, mir200, ZEB1, OVOL2, p63 and p300) and translational implications of the Grainyhead proteins in cancer are discussed in this review article.

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