The Dynamics of Tubulogenesis in Development and Disease

Overview

Journal Development

Specialty Biology

Date 2025 Feb 17

PMID 39959988

Authors

Adrian Romero

Brandy L Walker

Vanja Krneta-Stankic

Kamryn Gerner-Mauro

Lydia Youmans

Rachel K Miller

Affiliations

Soon will be listed here.

Abstract

Tubes are crucial for the function of many organs in animals given their fundamental roles in transporting and exchanging substances to maintain homeostasis within an organism. Therefore, the development and maintenance of these tube-like structures within organs is a vital process. Tubes can form in diverse ways, and advances in our understanding of the molecular and cellular mechanisms underpinning these different modes of tubulogenesis have significant impacts in many biological contexts, including development and disease. This Review discusses recent progress in understanding developmental mechanisms underlying tube formation.

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