Understanding Molecular Mechanisms in Cell Signaling Through Natural and Artificial Sequence Variation

Overview

Journal Nat Struct Mol Biol

Specialties Cell Biology
Molecular Biology

Date 2019 Jan 2

PMID 30598552

Citations 13

Authors

Neel H Shah

John Kuriyan

Affiliations

Soon will be listed here.

Abstract

The functionally tolerated sequence space of proteins can now be explored in an unprecedented way, owing to the expansion of genomic databases and the development of high-throughput methods to interrogate protein function. For signaling proteins, several recent studies have shown how the analysis of sequence variation leverages the available protein-structure information to provide new insights into specificity and allosteric regulation. In this Review, we discuss recent work that illustrates how this emerging approach is providing a deeper understanding of signaling proteins.

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