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Neel H Shah

Explore the profile of Neel H Shah including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 43
Citations 1197
Followers 0
Related Specialties
Chemistry
Biochemistry
Biology
Top 10 Co-Authors
John Kuriyan
Tom W Muir
Arthur Weiss
Cassandra A Chartier
Marko Jovanovic
David Cowburn
Anne E van Vlimmeren
Deepti Karandur
Wan-Lin Lo
Rashmi Voleti
Published In
J Am Chem Soc
Elife
bioRxiv
Protein Sci
Proc Natl Acad Sci U S A
Affiliations
Soon will be listed here.
Recent Articles
1.
Allosteric inhibition rescues hydrocephalus caused by catalytically inactive Shp2
Makrides N, Sun E, Mir H, Jiang Z, Wu Y, Serra C, et al.
bioRxiv . 2025 Feb; PMID: 39974929
SHP2, a protein tyrosine phosphatase (PTP) crucial in Ras-MAPK signaling, is associated with various human congenital diseases and cancers. Here, we show that the catalytically inactive mutation results in communicating...
2.
SEC-MX: an approach to systematically study the interplay between protein assembly states and phosphorylation
Doron-Mandel E, Bokor B, Ma Y, Street L, Tang L, Abdou A, et al.
Nat Commun . 2025 Jan; 16(1):1176. PMID: 39885126
A protein's molecular interactions and post-translational modifications (PTMs), such as phosphorylation, can be co-dependent and reciprocally co-regulate each other. Although this interplay is central for many biological processes, a systematic...
3.
Accurate sequence-to-affinity models for SH2 domains from multi-round peptide binding assays coupled with free-energy regression
Gagoski D, Rube T, Rube H, Rastogi C, Melo L, Melo L, et al.
bioRxiv . 2025 Jan; PMID: 39764007
Short linear peptide motifs play important roles in cell signaling. They can act as modification sites for enzymes and as recognition sites for peptide binding domains. SH2 domains bind specifically...
4.
Allosteric regulation of the tyrosine phosphatase PTP1B by a protein-protein interaction
Chartier C, Woods V, Xu Y, van Vlimmeren A, Johns A, Jovanovic M, et al.
Protein Sci . 2024 Dec; 34(1):e70016. PMID: 39723820
The rapid identification of protein-protein interactions has been significantly enabled by mass spectrometry (MS) proteomics-based methods, including affinity purification-MS, crosslinking-MS, and proximity-labeling proteomics. While these methods can reveal networks of...
5.
Deep mutational scanning of a multi-domain signaling protein reveals mechanisms of regulation and pathogenicity
Jiang Z, van Vlimmeren A, Karandur D, Semmelman A, Shah N
bioRxiv . 2024 Aug; PMID: 39091798
Multi-domain signaling enzymes are often regulated through extensive inter-domain interactions, and disruption of inter-domain interfaces by mutations can lead to aberrant signaling and diseases. For example, the tyrosine phosphatase SHP2...
6.
Allosteric regulation of the tyrosine phosphatase PTP1B by a protein-protein interaction
Chartier C, Woods V, Xu Y, van Vlimmeren A, Johns A, Jovanovic M, et al.
bioRxiv . 2024 Jul; PMID: 39071364
The rapid identification of protein-protein interactions has been significantly enabled by mass spectrometry (MS) proteomics-based methods, including affinity purification-MS, crosslinking-MS, and proximity-labeling proteomics. While these methods can reveal networks of...
7.
Crafting Unnatural Peptide Macrocycles via Rh(III)-Catalyzed Carboamidation
Lamartina C, Chartier C, Hirano J, Shah N, Rovis T
J Am Chem Soc . 2024 Jul; 146(30):20868-20877. PMID: 39024122
Contemporary developments in the field of peptide macrocyclization methodology are imperative for enabling the advance of drug design in medicinal chemistry. This report discloses a Rh(III)-catalyzed macrocyclization via carboamidation, reacting...
8.
The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domain
van Vlimmeren A, Voleti R, Chartier C, Jiang Z, Karandur D, Humphries P, et al.
Proc Natl Acad Sci U S A . 2024 Jul; 121(30):e2407159121. PMID: 39012820
Mutations in the tyrosine phosphatase Src homology-2 domain-containing protein tyrosine phosphatase-2 (SHP2) are associated with a variety of human diseases. Most mutations in SHP2 increase its basal catalytic activity by...
9.
Photocatalytic Activation of Aryl(trifluoromethyl) Diazos to Carbenes for High-Resolution Protein Labeling with Red Light
Cabanero D, Kariofillis S, Johns A, Kim J, Ni J, Park S, et al.
J Am Chem Soc . 2024 Jan; 146(2):1337-1345. PMID: 38165744
State-of-the-art methods in photoproximity labeling center on the targeted generation and capture of short-lived reactive intermediates to provide a snapshot of local protein environments. Diazirines are the current gold standard...
10.
TCR signaling promotes formation of an STS1-Cbl-b complex with pH-sensitive phosphatase activity that suppresses T cell function in acidic environments
Tsai Y, Arias-Badia M, Kadlecek T, Lwin Y, Srinath A, Shah N, et al.
Immunity . 2023 Dec; 56(12):2682-2698.e9. PMID: 38091950
T cell responses are inhibited by acidic environments. T cell receptor (TCR)-induced protein phosphorylation is negatively regulated by dephosphorylation and/or ubiquitination, but the mechanisms underlying sensitivity to acidic environments are...