Exercise Training Augments Sirt1-signaling and Attenuates Cardiac Inflammation in D-galactose Induced-aging Rats

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2018 Dec 25

PMID 30582744

Citations 32

Authors

Wei-Kung Chen

Ying-Lan Tsai

Marthandam Asokan Shibu

Chia-Yao Shen

Shu Nu Chang-Lee

Ray-Jade Chen

Chun-Hsu Yao

Bo Ban

Wei-Wen Kuo

Chih-Yang Huang

Affiliations

Soon will be listed here.

Abstract

Exercise is known to be beneficial in controlling aging associated disorders however, the consequence of long-term exercise on cardiac health among aging population is not much clear. In this study the protective effect of exercise on aging associated cardiac disorders was determined using a D-galactose-induced aging model. Eight weeks old Sprague Dawley rats were given intraperitoneal injection of 150 mL/kg D-galactose. Swimming exercise was provided in warm water for 60 min/day for five days per week. Hematoxylin and eosin staining of cardiac tissue sections revealed cardiomyocyte disarrangements in the aging rat hearts but long-term exercise training showed improvements in the cardiac histology. Exercise training also enhanced the expression levels of proteins such as SIRT1, PGC-1α and AMPKα1 that are associated with energy homeostasis and further suppressed aging associated inflammatory cytokines. Our results show that long-term exercise training potentially enhances SIRT1 associated anti-aging signaling and provide cardio-protection against aging.

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