NF-kappaB Signaling in Skeletal Muscle: Prospects for Intervention in Muscle Diseases

Overview

Journal J Mol Med (Berl)

Specialty General Medicine

Date 2008 Feb 5

PMID 18246321

Citations 58

Authors

Foteini Mourkioti

Nadia Rosenthal

Affiliations

Soon will be listed here.

Abstract

Muscle remodeling is an important physiological process that promotes adaptive changes in cytoarchitecture and protein composition after exercise, aging, or disease conditions. Numerous transcription factors have been reported to regulate skeletal muscle homeostasis. NF-kappaB is a major pleiotropic transcription factor modulating immune, inflammatory, cell survival, and proliferating responses; however, its role in muscle development, physiology, and disease has just started to be elucidated. The current review article aims to summarize the literature on the role of NF-kappaB signaling in skeletal muscle pathophysiology, investigated over the last years using in vitro and more recently in vivo systems. Understanding the exact role of NF-kappaB in muscle cells will allow better therapeutic manipulations in the setting of human muscle diseases.

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References

van Loo G, De Lorenzi R, Schmidt H, Huth M, Mildner A, Schmidt-Supprian M . Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice. Nat Immunol. 2006; 7(9):954-61. DOI: 10.1038/ni1372. View

Mourkioti F, Kratsios P, Luedde T, Song Y, Delafontaine P, Adami R . Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration. J Clin Invest. 2006; 116(11):2945-54. PMC: 1626136. DOI: 10.1172/JCI28721. View

Judge A, Koncarevic A, Hunter R, Liou H, Jackman R, Kandarian S . Role for IkappaBalpha, but not c-Rel, in skeletal muscle atrophy. Am J Physiol Cell Physiol. 2006; 292(1):C372-82. DOI: 10.1152/ajpcell.00293.2006. View

Monici M, Aguennouz M, Mazzeo A, Messina C, Vita G . Activation of nuclear factor-kappaB in inflammatory myopathies and Duchenne muscular dystrophy. Neurology. 2003; 60(6):993-7. DOI: 10.1212/01.wnl.0000049913.27181.51. View

Wu Z, Shi Y, Tibbetts R, Miyamoto S . Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Science. 2006; 311(5764):1141-6. DOI: 10.1126/science.1121513. View

Baghdiguian S, Martin M, Richard I, Pons F, Astier C, Bourg N . Calpain 3 deficiency is associated with myonuclear apoptosis and profound perturbation of the IkappaB alpha/NF-kappaB pathway in limb-girdle muscular dystrophy type 2A. Nat Med. 1999; 5(5):503-11. DOI: 10.1038/8385. View

Kaufman C, Fuchs E . It's got you covered. NF-kappaB in the epidermis. J Cell Biol. 2000; 149(5):999-1004. PMC: 2174820. DOI: 10.1083/jcb.149.5.999. View

Moldawer L, Svaninger G, Gelin J, Lundholm K . Interleukin 1 and tumor necrosis factor do not regulate protein balance in skeletal muscle. Am J Physiol. 1987; 253(6 Pt 1):C766-73. DOI: 10.1152/ajpcell.1987.253.6.C766. View

Hu Y, Baud V, Oga T, Kim K, Yoshida K, Karin M . IKKalpha controls formation of the epidermis independently of NF-kappaB. Nature. 2001; 410(6829):710-4. DOI: 10.1038/35070605. View

10.

Hu M, Lee D, Xia W, Golfman L, Ou-Yang F, Yang J . IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell. 2004; 117(2):225-37. DOI: 10.1016/s0092-8674(04)00302-2. View

11.

Baghdiguian S, Richard I, Martin M, Coopman P, Beckmann J, Mangeat P . Pathophysiology of limb girdle muscular dystrophy type 2A: hypothesis and new insights into the IkappaBalpha/NF-kappaB survival pathway in skeletal muscle. J Mol Med (Berl). 2001; 79(5-6):254-61. DOI: 10.1007/s001090100225. View

12.

Wang H, Hertlein E, Bakkar N, Sun H, Acharyya S, Wang J . NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes. Mol Cell Biol. 2007; 27(12):4374-87. PMC: 1900043. DOI: 10.1128/MCB.02020-06. View

13.

Hunter R, Kandarian S . Disruption of either the Nfkb1 or the Bcl3 gene inhibits skeletal muscle atrophy. J Clin Invest. 2004; 114(10):1504-11. PMC: 525738. DOI: 10.1172/JCI21696. View

14.

Guttridge D, Mayo M, Madrid L, Wang C, Baldwin Jr A . NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia. Science. 2000; 289(5488):2363-6. DOI: 10.1126/science.289.5488.2363. View

15.

Cai D, Frantz J, Tawa Jr N, Melendez P, Oh B, Lidov H . IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell. 2004; 119(2):285-98. DOI: 10.1016/j.cell.2004.09.027. View

16.

Ladner K, Caligiuri M, Guttridge D . Tumor necrosis factor-regulated biphasic activation of NF-kappa B is required for cytokine-induced loss of skeletal muscle gene products. J Biol Chem. 2002; 278(4):2294-303. DOI: 10.1074/jbc.M207129200. View

17.

Emery A . The muscular dystrophies. Lancet. 2002; 359(9307):687-95. DOI: 10.1016/S0140-6736(02)07815-7. View

18.

Bulfield G, Siller W, Wight P, Moore K . X chromosome-linked muscular dystrophy (mdx) in the mouse. Proc Natl Acad Sci U S A. 1984; 81(4):1189-92. PMC: 344791. DOI: 10.1073/pnas.81.4.1189. View

19.

Chen Z . Ubiquitin signalling in the NF-kappaB pathway. Nat Cell Biol. 2005; 7(8):758-65. PMC: 1551980. DOI: 10.1038/ncb0805-758. View

20.

Coletti D, Moresi V, Adamo S, Molinaro M, Sassoon D . Tumor necrosis factor-alpha gene transfer induces cachexia and inhibits muscle regeneration. Genesis. 2005; 43(3):120-8. DOI: 10.1002/gene.20160. View