Transcriptome-wide Reprogramming of N-methyladenosine Modification by the Mouse Microbiome

Overview

Journal Cell Res

Specialty Cell Biology

Date 2018 Dec 19

PMID 30559439

Citations 28

Authors

Xiaoyun Wang

Yan Li

Wenjun Chen

Hailing Shi

A Murat Eren

Aleksey Morozov

Chuan He

Guan-Zheng Luo

Tao Pan

Affiliations

Soon will be listed here.

Citing Articles

Interplay of m6A RNA methylation and gut microbiota in modulating gut injury.

Wang H, Han J, Zhang X Gut Microbes. 2025; 17(1):2467213.

PMID: 39960310 PMC: 11834532. DOI: 10.1080/19490976.2025.2467213.

Gut Microbiota-Derived Hyocholic Acid Enhances Type 3 Immunity and Protects Against Salmonella enterica Serovar Typhimurium in Neonatal Rats.

Yang Z, Lin Z, You Y, Zhang M, Gao N, Wang X Adv Sci (Weinh). 2024; 12(10):e2412071.

PMID: 39737849 PMC: 11905087. DOI: 10.1002/advs.202412071.

Research Progress on the Role of M6A in Regulating Economic Traits in Livestock.

Ren T, Xu M, Du X, Wang Y, Loor J, Lei L Int J Mol Sci. 2024; 25(15).

PMID: 39125935 PMC: 11313175. DOI: 10.3390/ijms25158365.

Nurturing gut health: role of m6A RNA methylation in upholding the intestinal barrier.

Wang S, Yang Y, Jiang X, Zheng X, Wei Q, Dai W Cell Death Discov. 2024; 10(1):271.

PMID: 38830900 PMC: 11148167. DOI: 10.1038/s41420-024-02043-x.

Antibiotic-Induced Gut Microbiota Dysbiosis Modulates Host Transcriptome and mA Epitranscriptome via Bile Acid Metabolism.

Yang M, Zheng X, Fan J, Cheng W, Yan T, Lai Y Adv Sci (Weinh). 2024; 11(28):e2307981.

PMID: 38713722 PMC: 11267274. DOI: 10.1002/advs.202307981.

References

Pan W, Sommer F, Falk-Paulsen M, Ulas T, Best L, Fazio A . Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development. Genome Med. 2018; 10(1):27. PMC: 5899322. DOI: 10.1186/s13073-018-0534-5. View

Braniste V, Al-Asmakh M, Kowal C, Anuar F, Abbaspour A, Toth M . The gut microbiota influences blood-brain barrier permeability in mice. Sci Transl Med. 2014; 6(263):263ra158. PMC: 4396848. DOI: 10.1126/scitranslmed.3009759. View

Yang Y, Hsu P, Chen Y, Yang Y . Dynamic transcriptomic mA decoration: writers, erasers, readers and functions in RNA metabolism. Cell Res. 2018; 28(6):616-624. PMC: 5993786. DOI: 10.1038/s41422-018-0040-8. View

Deng X, Su R, Weng H, Huang H, Li Z, Chen J . RNA N-methyladenosine modification in cancers: current status and perspectives. Cell Res. 2018; 28(5):507-517. PMC: 5951805. DOI: 10.1038/s41422-018-0034-6. View

Xiao W, Adhikari S, Dahal U, Chen Y, Hao Y, Sun B . Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing. Mol Cell. 2016; 61(4):507-519. DOI: 10.1016/j.molcel.2016.01.012. View

Luczynski P, McVey Neufeld K, Oriach C, Clarke G, Dinan T, Cryan J . Growing up in a Bubble: Using Germ-Free Animals to Assess the Influence of the Gut Microbiota on Brain and Behavior. Int J Neuropsychopharmacol. 2016; 19(8. PMC: 5006193. DOI: 10.1093/ijnp/pyw020. View

Selwyn F, Cui J, Klaassen C . RNA-Seq Quantification of Hepatic Drug Processing Genes in Germ-Free Mice. Drug Metab Dispos. 2015; 43(10):1572-80. PMC: 4576678. DOI: 10.1124/dmd.115.063545. View

Yoon K, Ringeling F, Vissers C, Jacob F, Pokrass M, Jimenez-Cyrus D . Temporal Control of Mammalian Cortical Neurogenesis by mA Methylation. Cell. 2017; 171(4):877-889.e17. PMC: 5679435. DOI: 10.1016/j.cell.2017.09.003. View

Romano K, Martinez-Del Campo A, Kasahara K, Chittim C, Vivas E, Amador-Noguez D . Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption. Cell Host Microbe. 2017; 22(3):279-290.e7. PMC: 5599363. DOI: 10.1016/j.chom.2017.07.021. View

10.

Roundtree I, Evans M, Pan T, He C . Dynamic RNA Modifications in Gene Expression Regulation. Cell. 2017; 169(7):1187-1200. PMC: 5657247. DOI: 10.1016/j.cell.2017.05.045. View

11.

Diaz Heijtz R, Wang S, Anuar F, Qian Y, Bjorkholm B, Samuelsson A . Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci U S A. 2011; 108(7):3047-52. PMC: 3041077. DOI: 10.1073/pnas.1010529108. View

12.

Choi J, Ieong K, Demirci H, Chen J, Petrov A, Prabhakar A . N(6)-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics. Nat Struct Mol Biol. 2016; 23(2):110-5. PMC: 4826618. DOI: 10.1038/nsmb.3148. View

13.

Meyer K, Patil D, Zhou J, Zinoviev A, Skabkin M, Elemento O . 5' UTR m(6)A Promotes Cap-Independent Translation. Cell. 2015; 163(4):999-1010. PMC: 4695625. DOI: 10.1016/j.cell.2015.10.012. View

14.

Liu N, Dai Q, Zheng G, He C, Parisien M, Pan T . N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. Nature. 2015; 518(7540):560-4. PMC: 4355918. DOI: 10.1038/nature14234. View

15.

Wang X, Lu Z, Gomez A, Hon G, Yue Y, Han D . N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2013; 505(7481):117-20. PMC: 3877715. DOI: 10.1038/nature12730. View