A Population-based Cohort Study to Evaluate the Effectiveness of Lung Cancer Screening Using Low-dose CT in Hitachi City, Japan

Overview

Journal Jpn J Clin Oncol

Publisher Oxford University Press

Specialty Oncology

Date 2018 Dec 13

PMID 30541133

Citations 14

Authors

Takeshi Nawa

Keisuke Fukui

Tomio Nakayama

Motoyasu Sagawa

Tohru Nakagawa

Hideo Ichimura

Tetsuya Mizoue

Affiliations

Soon will be listed here.

Abstract

Objectives: To evaluate the effectiveness of lung cancer screening using low-dose computed tomography for the general population, we conducted a retrospective cohort study of screening for participants among Hitachi residents.

Materials And Methods: Citizens aged 50-74 who underwent low-dose computed tomography screening at least once during 1998-2006 were defined as the computed tomography group, and those who underwent X-ray screening at least once during the same period, but did not receive low-dose computed tomography screening throughout the follow-up period, were defined as the XP group. We investigated the lung cancer incidence rate, mortality rate and all-cause mortality rate for both groups from the first lung cancer screening to the end of 2012.

Results: In the computed tomography group (17 935 residents; 9790 males and 8145 females), 273 cases of lung cancer (1.5%), 72 cases of lung cancer death (0.4%), and 885 cases of all-cause death (4.9%) were observed. On the other hand, 164 cases (1.1%) of lung cancer, 80 cases (0.5%) of lung cancer death and 1188 cases (7.6%) of all-cause death were observed in the XP group (15 548 residents; 6526 males and 9022 females). The hazard ratios of the computed tomography group to the XP group adjusted for gender, age and smoking history were 1.23 for lung cancer incidence rate, 0.49 for lung cancer mortality rate and 0.57 for all-cause mortality rate. Non-smokers and light smokers (<30 pack-years) had a significantly lower lung cancer mortality (0.41 and 0.21, respectively).

Conclusion: low-dose computed tomography screening for a population including non-smokers and light smokers may be effective.

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References

Sone S, Li F, Yang Z, Honda T, Maruyama Y, Takashima S . Results of three-year mass screening programme for lung cancer using mobile low-dose spiral computed tomography scanner. Br J Cancer. 2001; 84(1):25-32. PMC: 2363609. DOI: 10.1054/bjoc.2000.1531. View

Sobue T, Moriyama N, Kaneko M, Kusumoto M, Kobayashi T, Tsuchiya R . Screening for lung cancer with low-dose helical computed tomography: anti-lung cancer association project. J Clin Oncol. 2002; 20(4):911-20. DOI: 10.1200/JCO.2002.20.4.911. View

Nawa T, Nakagawa T, Kusano S, Kawasaki Y, Sugawara Y, Nakata H . Lung cancer screening using low-dose spiral CT: results of baseline and 1-year follow-up studies. Chest. 2002; 122(1):15-20. DOI: 10.1378/chest.122.1.15. View

Sagawa M, Nakayama T, Tsukada H, Nishii K, Baba T, Kurita Y . The efficacy of lung cancer screening conducted in 1990s: four case-control studies in Japan. Lung Cancer. 2003; 41(1):29-36. DOI: 10.1016/s0169-5002(03)00197-1. View

Hamashima C, Sobue T, Muramatsu Y, Saito H, Moriyama N, Kakizoe T . Comparison of observed and expected numbers of detected cancers in the research center for cancer prevention and screening program. Jpn J Clin Oncol. 2006; 36(5):301-8. DOI: 10.1093/jjco/hyl022. View

Thun M, Hannan L, Adams-Campbell L, Boffetta P, Buring J, Feskanich D . Lung cancer occurrence in never-smokers: an analysis of 13 cohorts and 22 cancer registry studies. PLoS Med. 2008; 5(9):e185. PMC: 2531137. DOI: 10.1371/journal.pmed.0050185. View

Aberle D, Adams A, Berg C, Black W, Clapp J, Fagerstrom R . Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011; 365(5):395-409. PMC: 4356534. DOI: 10.1056/NEJMoa1102873. View

Nawa T, Nakagawa T, Mizoue T, Kusano S, Chonan T, Fukai S . Long-term prognosis of patients with lung cancer detected on low-dose chest computed tomography screening. Lung Cancer. 2011; 75(2):197-202. DOI: 10.1016/j.lungcan.2011.07.002. View

Oken M, Hocking W, Kvale P, Andriole G, Buys S, Church T . Screening by chest radiograph and lung cancer mortality: the Prostate, Lung, Colorectal, and Ovarian (PLCO) randomized trial. JAMA. 2011; 306(17):1865-73. DOI: 10.1001/jama.2011.1591. View

10.

Sagawa M, Nakayama T, Tanaka M, Sakuma T, Sobue T . A randomized controlled trial on the efficacy of thoracic CT screening for lung cancer in non-smokers and smokers of <30 pack-years aged 50-64 years (JECS study): research design. Jpn J Clin Oncol. 2012; 42(12):1219-21. DOI: 10.1093/jjco/hys157. View

11.

Nawa T, Nakagawa T, Mizoue T, Kusano S, Chonan T, Hayashihara K . A decrease in lung cancer mortality following the introduction of low-dose chest CT screening in Hitachi, Japan. Lung Cancer. 2012; 78(3):225-8. DOI: 10.1016/j.lungcan.2012.09.012. View

12.

Patz Jr E, Pinsky P, Gatsonis C, Sicks J, Kramer B, Tammemagi M . Overdiagnosis in low-dose computed tomography screening for lung cancer. JAMA Intern Med. 2013; 174(2):269-74. PMC: 4040004. DOI: 10.1001/jamainternmed.2013.12738. View

13.

Carter J, Coletti R, Harris R . Quantifying and monitoring overdiagnosis in cancer screening: a systematic review of methods. BMJ. 2015; 350:g7773. PMC: 4332263. DOI: 10.1136/bmj.g7773. View

14.

Chin J, Syrek Jensen T, Ashby L, Hermansen J, Hutter J, Conway P . Screening for lung cancer with low-dose CT--translating science into Medicare coverage policy. N Engl J Med. 2015; 372(22):2083-5. DOI: 10.1056/NEJMp1502598. View

15.

Kakinuma R, Noguchi M, Ashizawa K, Kuriyama K, Maeshima A, Koizumi N . Natural History of Pulmonary Subsolid Nodules: A Prospective Multicenter Study. J Thorac Oncol. 2016; 11(7):1012-28. DOI: 10.1016/j.jtho.2016.04.006. View

16.

Hori M, Tanaka H, Wakai K, Sasazuki S, Katanoda K . Secondhand smoke exposure and risk of lung cancer in Japan: a systematic review and meta-analysis of epidemiologic studies. Jpn J Clin Oncol. 2016; 46(10):942-951. PMC: 5063005. DOI: 10.1093/jjco/hyw091. View

17.

Yousaf-Khan U, van der Aalst C, de Jong P, Heuvelmans M, Scholten E, Walter J . Risk stratification based on screening history: the NELSON lung cancer screening study. Thorax. 2017; 72(9):819-824. DOI: 10.1136/thoraxjnl-2016-209892. View

18.

Cufari M, Proli C, De Sousa P, Raubenheimer H, Al Sahaf M, Chavan H . Increasing frequency of non-smoking lung cancer: Presentation of patients with early disease to a tertiary institution in the UK. Eur J Cancer. 2017; 84:55-59. DOI: 10.1016/j.ejca.2017.06.031. View

19.

Henschke C, Salvatore M, Cham M, Powell C, Difabrizio L, Flores R . Baseline and annual repeat rounds of screening: implications for optimal regimens of screening. Eur Radiol. 2017; 28(3):1085-1094. DOI: 10.1007/s00330-017-5029-z. View

20.

Oudkerk M, Devaraj A, Vliegenthart R, Henzler T, Prosch H, Heussel C . European position statement on lung cancer screening. Lancet Oncol. 2017; 18(12):e754-e766. DOI: 10.1016/S1470-2045(17)30861-6. View