The Peculiar Genetics of the Ribosomal DNA Blurs the Boundaries of Transgenerational Epigenetic Inheritance

Overview

Journal Chromosome Res

Date 2018 Dec 5

PMID 30511202

Citations 7

Authors

Farah Bughio

Keith A Maggert

Affiliations

Soon will be listed here.

Abstract

Our goal is to draw a line-hypothetical in its totality but experimentally supported at each individual step-connecting the ribosomal DNA and the phenomenon of transgenerational epigenetic inheritance of induced phenotypes. The reasonableness of this hypothesis is offset by its implication, that many (or most) (or all) of the cases of induced-and-inherited phenotypes that are seen to persist for generations are instead unmapped induced polymorphisms in the ribosomal DNA, and thus are the consequence of the peculiar and enduringly fascinating genetics of the highly transcribed repeat DNA structure at that locus.

Citing Articles

Under the magnifying glass: The ups and downs of rDNA copy number.

Kindelay S, Maggert K Semin Cell Dev Biol. 2022; 136:38-48.

PMID: 35595601 PMC: 9976841. DOI: 10.1016/j.semcdb.2022.05.006.

Genetic variation at mouse and human ribosomal DNA influences associated epigenetic states.

Rodriguez-Algarra F, Seaborne R, Danson A, Yildizoglu S, Yoshikawa H, Law P Genome Biol. 2022; 23(1):54.

PMID: 35164830 PMC: 8842540. DOI: 10.1186/s13059-022-02617-x.

Variability of Human rDNA.

Smirnov E, Chmurciakova N, Liska F, Bazantova P, Cmarko D Cells. 2021; 10(2).

PMID: 33498263 PMC: 7909238. DOI: 10.3390/cells10020196.

The Utility of Graph Clustering of 5S Ribosomal DNA Homoeologs in Plant Allopolyploids, Homoploid Hybrids, and Cryptic Introgressants.

Garcia S, Wendel J, Borowska-Zuchowska N, Ainouche M, Kuderova A, Kovarik A Front Plant Sci. 2020; 11:41.

PMID: 32117380 PMC: 7025596. DOI: 10.3389/fpls.2020.00041.

Challenges and Approaches to Genotyping Repetitive DNA.

Morton E, Hall A, Kwan E, Mok C, Queitsch K, Nandakumar V G3 (Bethesda). 2019; 10(1):417-430.

PMID: 31757929 PMC: 6945026. DOI: 10.1534/g3.119.400771.

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