Theoretical Tool Bridging Cell Polarities with Development of Robust Morphologies

Overview

Journal Elife

Specialty Biology

Date 2018 Nov 28

PMID 30477635

Citations 11

Authors

Silas Boye Nissen

Steven Ronhild

Ala Trusina

Kim Sneppen

Affiliations

Soon will be listed here.

Abstract

Despite continual renewal and damages, a multicellular organism is able to maintain its complex morphology. How is this stability compatible with the complexity and diversity of living forms? Looking for answers at protein level may be limiting as diverging protein sequences can result in similar morphologies. Inspired by the progressive role of apical-basal and planar cell polarity in development, we propose that stability, complexity, and diversity are emergent properties in populations of proliferating polarized cells. We support our hypothesis by a theoretical approach, developed to effectively capture both types of polar cell adhesions. When applied to specific cases of development - gastrulation and the origins of folds and tubes - our theoretical tool suggests experimentally testable predictions pointing to the strength of polar adhesion, restricted directions of cell polarities, and the rate of cell proliferation to be major determinants of morphological diversity and stability.

Citing Articles

Effective mechanical potential of cell-cell interaction in tissues harboring cavity and in cell sheet toward morphogenesis.

Koyama H, Okumura H, Otani T, Ito A, Nakamura K, Kato K Front Cell Dev Biol. 2024; 12:1414601.

PMID: 39105171 PMC: 11298474. DOI: 10.3389/fcell.2024.1414601.

A computational analysis of the role of integrins and Rho-GTPases in the emergence and disruption of apical-basal polarization in renal epithelial cells.

Hagelaars M, Nikolic M, Vermeulen M, Dekker S, Bouten C, Loerakker S PLoS Comput Biol. 2024; 20(5):e1012140.

PMID: 38768266 PMC: 11142725. DOI: 10.1371/journal.pcbi.1012140.

Collective behavior and self-organization in neural rosette morphogenesis.

Miotto M, Rosito M, Paoluzzi M, de Turris V, Folli V, Leonetti M Front Cell Dev Biol. 2023; 11:1134091.

PMID: 37635866 PMC: 10448396. DOI: 10.3389/fcell.2023.1134091.

Effective mechanical potential of cell-cell interaction explains three-dimensional morphologies during early embryogenesis.

Koyama H, Okumura H, Ito A, Nakamura K, Otani T, Kato K PLoS Comput Biol. 2023; 19(8):e1011306.

PMID: 37549166 PMC: 10434874. DOI: 10.1371/journal.pcbi.1011306.

Spatial consistency of cell growth direction during organ morphogenesis requires CELLULOSE SYNTHASE INTERACTIVE1.

Mollier C, Skrzydel J, Borowska-Wykret D, Majda M, Bayle V, Battu V Cell Rep. 2023; 42(7):112689.

PMID: 37352099 PMC: 10391631. DOI: 10.1016/j.celrep.2023.112689.

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