Diphenyl Ethers from a Marine-Derived

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2018 Nov 21

PMID 30453472

Citations 9

Authors

Ya-Nan Wang

Yan-Hua Mou

Yu Dong

Yan Wu

Bing-Yu Liu

Jian Bai

Dao-Jiang Yan

Le Zhang

Dan-Qing Feng

Yue-Hu Pei

You-Cai Hu

Affiliations

Soon will be listed here.

Abstract

Six new diphenyl ethers (⁻) along with eleven known analogs were isolated from the ethyl acetate extract of a marine-derived guided by LC-UV-MS. Their structures were unambiguously characterized by HRESIMS, NMR, as well as chemical derivatization. Compounds and are rare diphenyl ether glycosides containing d-ribose. The absolute configuration of the sugar moieties in compounds ⁻ was determined by a LC-MS method. All the compounds were evaluated for their cytotoxicities against eight cancer cell lines, including 4T1, U937, PC3, HL-60, HT-29, A549, NCI-H460, and K562, and compounds , , , and ⁻ were found to exhibit selective cytotoxicity against different cancer cell lines.

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