Isolation and Characterization of Two New Metabolites from the Sponge-Derived Fungus Sp. LS34 by OSMAC Approach

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2019 May 15

PMID 31083492

Citations 9

Authors

Wei Li

Lijian Ding

Ning Wang

Jianzhou Xu

Weiyan Zhang

Bin Zhang

Shan He

Bin Wu

Haixiao Jin

Affiliations

Soon will be listed here.

Abstract

The application of an OSMAC (One Strain-Many Compounds) approach on the sponge-derived fungus sp. LS34, using two different media including solid rice medium and potato dextrose broth (PDB) resulted in the isolation and identification of two new compounds, named asperspin A () and asperther A () along with seven known compounds -. Compounds - were detected in fungal extracts from rice medium, while compounds - were isolated from PDB medium. Their structures were unambiguously characterized by HRESIMS and NMR spectroscopic data. The growth inhibitory activity of these compounds against four pathogenic bacteria (, , , and ) were evaluated. All the compounds were also tested for their cytotoxicity against seven cancer cell lines, including CCRF-CEM, K562, BGC823, AGS, HCT-116, MDA-MB-453, and COR-L23. Among them, compound showed strong activity against CCRF-CEM and K562 cells with IC values of 1.22 ± 0.05 µM and 10.58 ± 0.19 µM, respectively. Notably, compound also showed pronounced activity against with an MIC value of 3.54 µM.

Citing Articles

Multigene phylogeny, bioactive properties, enzymatic and dye decolorization potential of selected marine fungi from brown algae and sponges of Mauritius.

Wong Chin J, Puchooa D, Bahorun T, Alrefaei A, Neergheen V, Jeewon R Heliyon. 2024; 10(7):e28955.

PMID: 38623192 PMC: 11016617. DOI: 10.1016/j.heliyon.2024.e28955.

Pestalotiopols E-J, Six New Polyketide Derivatives from a Marine Derived Fungus sp. SWMU-WZ04-1.

Jiang L, Teng B, Zhang M, Chen S, Zhang D, Zhai L Mar Drugs. 2024; 22(1).

PMID: 38248640 PMC: 10820063. DOI: 10.3390/md22010015.

Advances in Natural Products from the Marine-Sponge-Associated Microorganisms with Antimicrobial Activity in the Last Decade.

Liang J, She J, Fu J, Wang J, Ye Y, Yang B Mar Drugs. 2023; 21(4).

PMID: 37103375 PMC: 10143917. DOI: 10.3390/md21040236.

Genomic Analysis and Antimicrobial Components of M7, an Strain Derived from the South China Sea.

Qi J, Chen C, He Y, Wang Y J Fungi (Basel). 2022; 8(10).

PMID: 36294615 PMC: 9605573. DOI: 10.3390/jof8101051.

Absolute configuration of cytotoxic anthraquinones from a Brazilian cave soil-derived fungus, Aspergillus sp. SDC28.

Gubiani J, Bernardi D, De Paula C, Seleghim M, Ferreira A, Batista A Arch Pharm (Weinheim). 2022; 355(4):e2100441.

PMID: 35099085 PMC: 8983557. DOI: 10.1002/ardp.202100441.

References

Hamann M, Otto C, Scheuer P, Dunbar D . Kahalalides: Bioactive Peptides from a Marine Mollusk Elysia rufescens and Its Algal Diet Bryopsis sp.(1). J Org Chem. 1996; 61(19):6594-6600. DOI: 10.1021/jo960877+. View

Bugni T, Ireland C . Marine-derived fungi: a chemically and biologically diverse group of microorganisms. Nat Prod Rep. 2004; 21(1):143-63. DOI: 10.1039/b301926h. View

Fotakis G, Timbrell J . In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicol Lett. 2005; 160(2):171-7. DOI: 10.1016/j.toxlet.2005.07.001. View

Shao H, Qin X, Dong Z, Zhang H, Liu J . Induced daldinin A, B, C with a new skeleton from cultures of the ascomycete Daldinia concentrica. J Antibiot (Tokyo). 2008; 61(3):115-9. DOI: 10.1038/ja.2008.119. View

Wu B, Wu X, Sun M, Li M . Two novel tyrosinase inhibitory sesquiterpenes induced by CuCl2 from a marine-derived fungus Pestalotiopsis sp. Z233. Mar Drugs. 2013; 11(8):2713-21. PMC: 3766860. DOI: 10.3390/md11082713. View

Sun Y, Bao J, Liu K, Zhang X, He F, Wang Y . Cytotoxic dihydrothiophene-condensed chromones from the marine-derived fungus Penicillium oxalicum. Planta Med. 2013; 79(15):1474-9. DOI: 10.1055/s-0033-1350805. View

Wang W, Li D, Li Y, Hua H, Ma E, Li Z . Caryophyllene sesquiterpenes from the marine-derived fungus Ascotricha sp. ZJ-M-5 by the one strain-many compounds strategy. J Nat Prod. 2014; 77(6):1367-71. DOI: 10.1021/np500110z. View

Zhao D, Shao C, Gan L, Wang M, Wang C . Chromone derivatives from a sponge-derived strain of the fungus Corynespora cassiicola. J Nat Prod. 2015; 78(2):286-93. DOI: 10.1021/np5009152. View

Zorofchian Moghadamtousi S, Nikzad S, Kadir H, AbuBakar S, Zandi K . Potential Antiviral Agents from Marine Fungi: An Overview. Mar Drugs. 2015; 13(7):4520-38. PMC: 4515631. DOI: 10.3390/md13074520. View

10.

Yurchenko A, Smetanina O, Kalinovsky A, Kirichuk N, Pivkin M, Ivanets E . New Metabolites from a Marine Sediment-Derived Fungus, Aspergillus carneus. Nat Prod Commun. 2015; 10(7):1247-50. View

11.

Huang Z, Nong X, Ren Z, Wang J, Zhang X, Qi S . Anti-HSV-1, antioxidant and antifouling phenolic compounds from the deep-sea-derived fungus Aspergillus versicolor SCSIO 41502. Bioorg Med Chem Lett. 2017; 27(4):787-791. DOI: 10.1016/j.bmcl.2017.01.032. View

12.

Wang W, Chen R, Luo Z, Wang W, Chen J . Antimicrobial activity and molecular docking studies of a novel anthraquinone from a marine-derived fungus Aspergillus versicolor. Nat Prod Res. 2017; 32(5):558-563. DOI: 10.1080/14786419.2017.1329732. View

13.

Li X, Xia Z, Tang J, Wu J, Tong J, Li M . Identification and Biological Evaluation of Secondary Metabolites from Marine Derived Fungi-Aspergillus sp. SCSIOW3, Cultivated in the Presence of Epigenetic Modifying Agents. Molecules. 2017; 22(8). PMC: 6152046. DOI: 10.3390/molecules22081302. View

14.

Fang F, Zhao J, Ding L, Huang C, Naman C, He S . 5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34. Mar Drugs. 2017; 15(8). PMC: 5577614. DOI: 10.3390/md15080260. View

15.

Tan Y, Yang B, Lin X, Luo X, Pang X, Tang L . Nitrobenzoyl Sesquiterpenoids with Cytotoxic Activities from a Marine-Derived Aspergillus ochraceus Fungus. J Nat Prod. 2018; 81(1):92-97. DOI: 10.1021/acs.jnatprod.7b00698. View

16.

Yu H, Wang X, Zhang Y, Xu W, Zhang J, Zhou X . Libertellenones O-S and Eutypellenones A and B, Pimarane Diterpene Derivatives from the Arctic Fungus Eutypella sp. D-1. J Nat Prod. 2018; 81(7):1553-1560. DOI: 10.1021/acs.jnatprod.8b00039. View

17.

Liu M, Sun W, Wang J, He Y, Zhang J, Li F . Bioactive secondary metabolites from the marine-associated fungus Aspergillus terreus. Bioorg Chem. 2018; 80:525-530. DOI: 10.1016/j.bioorg.2018.06.029. View

18.

Kang H, Zhang H, Zhong M, Ma L, Liu D, Liu W . Potential Antiviral Xanthones from a Coastal Saline Soil Fungus . Mar Drugs. 2018; 16(11). PMC: 6265927. DOI: 10.3390/md16110449. View

19.

Wang Y, Mou Y, Dong Y, Wu Y, Liu B, Bai J . Diphenyl Ethers from a Marine-Derived . Mar Drugs. 2018; 16(11). PMC: 6267227. DOI: 10.3390/md16110451. View

20.

Zhou Y, Ju G, Xiao L, Zhang X, Du F . Cyclodepsipeptides and Sesquiterpenes from Marine-Derived Fungus and Their Biological Functions. Mar Drugs. 2018; 16(12). PMC: 6316070. DOI: 10.3390/md16120519. View