Molecular Targets of Active Anticancer Compounds Derived from Marine Sources

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2018 May 23

PMID 29786660

Citations 12

Authors

Xiaoping Song

Ying Xiong

Xin Qi

Wei Tang

Jiajia Dai

Qianqun Gu

Jing Li

Affiliations

Soon will be listed here.

Abstract

Over the past decades, a number of novel compounds, which are produced in the marine environment, have been found to exhibit the anticancer effects. This review focuses on molecular targets of marine-derived anticancer candidates in clinical and preclinical studies. They are kinases, transcription factors, histone deacetylase, the ubiquitin-proteasome system, and so on. Specific emphasis of this review paper is to provide information on the optimization of new target compounds for future research and development of anticancer drugs, based on the identification of structures of these target molecules and parallel compounds.

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