Photoacoustic Imaging for Monitoring Periodontal Health: A First Human Study

Overview

Journal Photoacoustics

Date 2018 Nov 20

PMID 30450281

Citations 27

Authors

Colman Moore

Yuting Bai

Ali Hariri

Joan B Sanchez

Ching-Yu Lin

Sreenivas Koka

Parish Sedghizadeh

Casey Chen

Jesse V Jokerst

Affiliations

Soon will be listed here.

Abstract

The gold-standard periodontal probe is an aging tool that can detect periodontitis and monitor gingival health but is highly error-prone, does not fully characterize the periodontal pocket, and causes pain. Photoacoustic imaging is a noninvasive technique that can address these limitations. Here, a range of ultrasound frequencies between 16-40 MHz were used to image the periodontium and a contrast medium based on cuttlefish ink was used to label the pockets. A 40 MHz ultrasound frequency could spatially resolve the periodontal anatomy, including tooth, gum, gingival margin, and gingival thickness of tooth numbers 7-10 and 22-27. The photoacoustic-ultrasound measurements were more precise (0.01 mm) than those taken with physical probes by a dental hygienist. Furthermore, the full geometry of the pockets could be visualized with relative standard deviations of 10% (n = 5). This study shows the potential for non-invasive monitoring of periodontal health with photoacoustic-ultrasound imaging in the dental clinic.

Citing Articles

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References

Fan Q, Cheng K, Hu X, Ma X, Zhang R, Yang M . Transferring biomarker into molecular probe: melanin nanoparticle as a naturally active platform for multimodality imaging. J Am Chem Soc. 2014; 136(43):15185-94. PMC: 4227813. DOI: 10.1021/ja505412p. View

Attia A, Chuah S, Razansky D, Ho C, Malempati P, Dinish U . Noninvasive real-time characterization of non-melanoma skin cancers with handheld optoacoustic probes. Photoacoustics. 2017; 7:20-26. PMC: 5473546. DOI: 10.1016/j.pacs.2017.05.003. View

Vandenberghe B, Jacobs R, Bosmans H . Modern dental imaging: a review of the current technology and clinical applications in dental practice. Eur Radiol. 2010; 20(11):2637-55. DOI: 10.1007/s00330-010-1836-1. View

Savage A, Eaton K, Moles D, Needleman I . A systematic review of definitions of periodontitis and methods that have been used to identify this disease. J Clin Periodontol. 2009; 36(6):458-67. DOI: 10.1111/j.1600-051X.2009.01408.x. View

Knieling F, Neufert C, Hartmann A, Claussen J, Urich A, Egger C . Multispectral Optoacoustic Tomography for Assessment of Crohn's Disease Activity. N Engl J Med. 2017; 376(13):1292-1294. DOI: 10.1056/NEJMc1612455. View

Lehmann T, Troeltsch E, Spitzer K . Image processing and enhancement provided by commercial dental software programs. Dentomaxillofac Radiol. 2002; 31(4):264-72. DOI: 10.1038/sj.dmfr.4600707. View

Zackrisson S, van de Ven S, Gambhir S . Light in and sound out: emerging translational strategies for photoacoustic imaging. Cancer Res. 2014; 74(4):979-1004. PMC: 3944207. DOI: 10.1158/0008-5472.CAN-13-2387. View

Mariotti A, Hefti A . Defining periodontal health. BMC Oral Health. 2015; 15 Suppl 1:S6. PMC: 4580771. DOI: 10.1186/1472-6831-15-S1-S6. View

Stylogiannis A, Prade L, Buehler A, Aguirre J, Sergiadis G, Ntziachristos V . Continuous wave laser diodes enable fast optoacoustic imaging. Photoacoustics. 2018; 9:31-38. PMC: 5772504. DOI: 10.1016/j.pacs.2017.12.002. View

10.

Schou S, Holmstrup P, Stoltze K, Hjorting-Hansen E, Fiehn N, Skovgaard L . Probing around implants and teeth with healthy or inflamed peri-implant mucosa/gingiva. A histologic comparison in cynomolgus monkeys (Macaca fascicularis). Clin Oral Implants Res. 2002; 13(2):113-26. DOI: 10.1034/j.1600-0501.2002.130201.x. View

11.

Koka S . The implant-mucosal interface and its role in the long-term success of endosseous oral implants: a review of the literature. Int J Prosthodont. 1999; 11(5):421-32. View

12.

Liopo A, Su R, Oraevsky A . Melanin nanoparticles as a novel contrast agent for optoacoustic tomography. Photoacoustics. 2015; 3(1):35-43. PMC: 4398798. DOI: 10.1016/j.pacs.2015.02.001. View

13.

Jo J, Tian C, Xu G, Sarazin J, Schiopu E, Gandikota G . Photoacoustic tomography for human musculoskeletal imaging and inflammatory arthritis detection. Photoacoustics. 2019; 12:82-89. PMC: 6306364. DOI: 10.1016/j.pacs.2018.07.004. View

14.

Michaud D, Kelsey K, Papathanasiou E, Genco C, Giovannucci E . Periodontal disease and risk of all cancers among male never smokers: an updated analysis of the Health Professionals Follow-up Study. Ann Oncol. 2016; 27(5):941-7. PMC: 4843185. DOI: 10.1093/annonc/mdw028. View

15.

Beard P . Biomedical photoacoustic imaging. Interface Focus. 2012; 1(4):602-31. PMC: 3262268. DOI: 10.1098/rsfs.2011.0028. View

16.

Lin C, Chen F, Hariri A, Chen C, Wilder-Smith P, Takesh T . Photoacoustic Imaging for Noninvasive Periodontal Probing Depth Measurements. J Dent Res. 2017; 97(1):23-30. PMC: 5755810. DOI: 10.1177/0022034517729820. View

17.

Chuembou Pekam F, Marotti J, Wolfart S, Tinschert J, Radermacher K, Heger S . High-frequency ultrasound as an option for scanning of prepared teeth: an in vitro study. Ultrasound Med Biol. 2014; 41(1):309-16. DOI: 10.1016/j.ultrasmedbio.2014.08.023. View

18.

Eke P, Dye B, Wei L, Thornton-Evans G, Genco R . Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res. 2012; 91(10):914-20. DOI: 10.1177/0022034512457373. View

19.

Wang L, Hu S . Photoacoustic tomography: in vivo imaging from organelles to organs. Science. 2012; 335(6075):1458-62. PMC: 3322413. DOI: 10.1126/science.1216210. View

20.

Abbayya K, Puthanakar N, Naduwinmani S, Chidambar Y . Association between Periodontitis and Alzheimer's Disease. N Am J Med Sci. 2015; 7(6):241-6. PMC: 4488989. DOI: 10.4103/1947-2714.159325. View