Light in and Sound Out: Emerging Translational Strategies for Photoacoustic Imaging

Overview

Journal Cancer Res

Specialty Oncology

Date 2014 Feb 12

PMID 24514041

Citations 182

Authors

S Zackrisson

S M W Y van de Ven

S S Gambhir

Affiliations

Soon will be listed here.

Abstract

Photoacoustic imaging (PAI) has the potential for real-time molecular imaging at high resolution and deep inside the tissue, using nonionizing radiation and not necessarily depending on exogenous imaging agents, making this technique very promising for a range of clinical applications. The fact that PAI systems can be made portable and compatible with existing imaging technologies favors clinical translation even more. The breadth of clinical applications in which photoacoustics could play a valuable role include: noninvasive imaging of the breast, sentinel lymph nodes, skin, thyroid, eye, prostate (transrectal), and ovaries (transvaginal); minimally invasive endoscopic imaging of gastrointestinal tract, bladder, and circulating tumor cells (in vivo flow cytometry); and intraoperative imaging for assessment of tumor margins and (lymph node) metastases. In this review, we describe the basics of PAI and its recent advances in biomedical research, followed by a discussion of strategies for clinical translation of the technique.

Citing Articles

Towards photoacoustic human imaging: Shining a new light on clinical diagnostics.

Wang Z, Yang F, Zhang W, Xiong K, Yang S Fundam Res. 2024; 4(5):1314-1330.

PMID: 39431136 PMC: 11489505. DOI: 10.1016/j.fmre.2023.01.008.

Unsupervised denoising of photoacoustic images based on the Noise2Noise network.

Cheng Y, Zheng W, Bing R, Zhang H, Huang C, Huang P Biomed Opt Express. 2024; 15(8):4390-4405.

PMID: 39346987 PMC: 11427216. DOI: 10.1364/BOE.529253.

Recent Advances in Photoacoustic Imaging: Current Status and Future Perspectives.

Liu H, Teng X, Yu S, Yang W, Kong T, Liu T Micromachines (Basel). 2024; 15(8).

PMID: 39203658 PMC: 11356134. DOI: 10.3390/mi15081007.

Advancements and Challenges in the Application of Metal-Organic Framework (MOF) Nanocomposites for Tumor Diagnosis and Treatment.

Hou Y, Zhu C, Ban G, Shen Z, Liang Y, Chen K Int J Nanomedicine. 2024; 19:6295-6317.

PMID: 38919774 PMC: 11198007. DOI: 10.2147/IJN.S463144.

Xanthene-Based Dyes for Photoacoustic Imaging and their Use as Analyte-Responsive Probes.

Brondsted F, Stains C Chemistry. 2024; 30(37):e202400598.

PMID: 38662806 PMC: 11219268. DOI: 10.1002/chem.202400598.

References

Wick P, Clift M, Rosslein M, Rothen-Rutishauser B . A brief summary of carbon nanotubes science and technology: a health and safety perspective. ChemSusChem. 2011; 4(7):905-11. DOI: 10.1002/cssc.201100161. View

Jose J, Manohar S, Kolkman R, Steenbergen W, van Leeuwen T . Imaging of tumor vasculature using Twente photoacoustic systems. J Biophotonics. 2009; 2(12):701-17. DOI: 10.1002/jbio.200910025. View

Jokerst J, Cole A, Van de Sompel D, Gambhir S . Gold nanorods for ovarian cancer detection with photoacoustic imaging and resection guidance via Raman imaging in living mice. ACS Nano. 2012; 6(11):10366-77. PMC: 3572720. DOI: 10.1021/nn304347g. View

Galanzha E, Shashkov E, Spring P, Suen J, Zharov V . In vivo, noninvasive, label-free detection and eradication of circulating metastatic melanoma cells using two-color photoacoustic flow cytometry with a diode laser. Cancer Res. 2009; 69(20):7926-34. PMC: 2828368. DOI: 10.1158/0008-5472.CAN-08-4900. View

Favazza C, Jassim O, Cornelius L, Wang L . In vivo photoacoustic microscopy of human cutaneous microvasculature and a nevus. J Biomed Opt. 2011; 16(1):016015. PMC: 3055592. DOI: 10.1117/1.3528661. View

Song W, Wei Q, Feng L, Sarthy V, Jiao S, Liu X . Multimodal photoacoustic ophthalmoscopy in mouse. J Biophotonics. 2012; 6(6-7):505-512. PMC: 3986594. DOI: 10.1002/jbio.201200061. View

Koo J, Jeon M, Oh Y, Kang H, Kim J, Kim C . In vivo non-ionizing photoacoustic mapping of sentinel lymph nodes and bladders with ICG-enhanced carbon nanotubes. Phys Med Biol. 2012; 57(23):7853-62. DOI: 10.1088/0031-9155/57/23/7853. View

Lu W, Melancon M, Xiong C, Huang Q, Elliott A, Song S . Effects of photoacoustic imaging and photothermal ablation therapy mediated by targeted hollow gold nanospheres in an orthotopic mouse xenograft model of glioma. Cancer Res. 2011; 71(19):6116-21. PMC: 3185126. DOI: 10.1158/0008-5472.CAN-10-4557. View

Yavuz M, Cheng Y, Chen J, Cobley C, Zhang Q, Rycenga M . Gold nanocages covered by smart polymers for controlled release with near-infrared light. Nat Mater. 2009; 8(12):935-9. PMC: 2787748. DOI: 10.1038/nmat2564. View

10.

Manohar S, Kharine A, van Hespen J, Steenbergen W, van Leeuwen T . Photoacoustic mammography laboratory prototype: imaging of breast tissue phantoms. J Biomed Opt. 2004; 9(6):1172-81. DOI: 10.1117/1.1803548. View

11.

Pan D, Pramanik M, Senpan A, Ghosh S, Wickline S, Wang L . Near infrared photoacoustic detection of sentinel lymph nodes with gold nanobeacons. Biomaterials. 2010; 31(14):4088-93. PMC: 2874457. DOI: 10.1016/j.biomaterials.2010.01.136. View

12.

Su J, Karpiouk A, Wang B, Emelianov S . Photoacoustic imaging of clinical metal needles in tissue. J Biomed Opt. 2010; 15(2):021309. PMC: 2859083. DOI: 10.1117/1.3368686. View

13.

Yao J, Maslov K, Hu S, Wang L . Evans blue dye-enhanced capillary-resolution photoacoustic microscopy in vivo. J Biomed Opt. 2009; 14(5):054049. PMC: 2782364. DOI: 10.1117/1.3251044. View

14.

Xia W, Piras D, van Hespen J, van Veldhoven S, Prins C, van Leeuwen T . An optimized ultrasound detector for photoacoustic breast tomography. Med Phys. 2013; 40(3):032901. DOI: 10.1118/1.4792462. View

15.

Kim C, Cho E, Chen J, Song K, Au L, Favazza C . In vivo molecular photoacoustic tomography of melanomas targeted by bioconjugated gold nanocages. ACS Nano. 2010; 4(8):4559-64. PMC: 3065066. DOI: 10.1021/nn100736c. View

16.

Zhang H, Maslov K, Stoica G, Wang L . Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging. Nat Biotechnol. 2006; 24(7):848-51. DOI: 10.1038/nbt1220. View

17.

Akers W, Kim C, Berezin M, Guo K, Fuhrhop R, Lanza G . Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles. ACS Nano. 2010; 5(1):173-82. PMC: 3026895. DOI: 10.1021/nn102274q. View

18.

Chen Y, Frey W, Kim S, Kruizinga P, Homan K, Emelianov S . Silica-coated gold nanorods as photoacoustic signal nanoamplifiers. Nano Lett. 2011; 11(2):348-54. PMC: 3040682. DOI: 10.1021/nl1042006. View

19.

Qin C, Cheng K, Chen K, Hu X, Liu Y, Lan X . Tyrosinase as a multifunctional reporter gene for Photoacoustic/MRI/PET triple modality molecular imaging. Sci Rep. 2013; 3:1490. PMC: 3603217. DOI: 10.1038/srep01490. View

20.

Zhu B, Sevick-Muraca E . Reconstruction of sectional images in frequency-domain based photoacoustic imaging. Opt Express. 2011; 19(23):23286-97. DOI: 10.1364/OE.19.023286. View