Is Efficiency of Suppressor TRNAs Controlled at the Level of Ribosomal Proofreading in Vivo?

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1988 Aug 1

PMID 3042761

Citations 7

Authors

M Faxen

L A Kirsebom

L A ISAKSSON

Affiliations

Soon will be listed here.

Abstract

Ribosomal rpsD mutations did not stimulate nonsense suppressor tRNAs in a general manner according to their increased ribosomal ambiguity and decreased proofreading efficiency. Streptomycin, which stimulates error production by blocking proofreading in vitro, did not increase efficiency of suppressor tRNAs in strains with normal or streptomycin-resistant (rpsL) ribosomes. It did so only in combination with one rpsL mutation which is associated with streptomycin pseudodependence.

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References

Goodman H, Abelson J, Landy A, Brenner S, Smith J . Amber suppression: a nucleotide change in the anticodon of a tyrosine transfer RNA. Nature. 1968; 217(5133):1019-24. DOI: 10.1038/2171019a0. View

Diaz I, Pedersen S, Kurland C . Effects of miaA on translation and growth rates. Mol Gen Genet. 1987; 208(3):373-6. DOI: 10.1007/BF00328126. View

Hirsh D . Tryptophan transfer RNA as the UGA suppressor. J Mol Biol. 1971; 58(2):439-58. DOI: 10.1016/0022-2836(71)90362-7. View

Gefter M, Russell R . Role modifications in tyrosine transfer RNA: a modified base affecting ribosome binding. J Mol Biol. 1969; 39(1):145-57. DOI: 10.1016/0022-2836(69)90339-8. View

Rosset R, GORINI L . A ribosomal ambiguity mutation. J Mol Biol. 1969; 39(1):95-112. DOI: 10.1016/0022-2836(69)90336-2. View

Zimmermann R, Garvin R, GORINI L . Alteration of a 30S ribosomal protein accompanying the ram mutation in Escherichia coli. Proc Natl Acad Sci U S A. 1971; 68(9):2263-7. PMC: 389397. DOI: 10.1073/pnas.68.9.2263. View

GORINI L . Ribosomal discrimination of tRNAs. Nat New Biol. 1971; 234(52):261-4. DOI: 10.1038/newbio234261a0. View

Biswas D, GORINI L . Restriction, de-restriction and mistranslation in missense suppression. Ribosomal discrimination of transfer RNA's. J Mol Biol. 1972; 64(1):119-34. DOI: 10.1016/0022-2836(72)90324-5. View

Ninio J . A semi-quantitative treatment of missense and nonsense suppression in the strA and ram ribosomal mutants of Escherichia coli. Evaluation of some molecular parameters of translation in vivo. J Mol Biol. 1974; 84(2):297-313. DOI: 10.1016/0022-2836(74)90586-5. View

10.

Neidhardt F, Bloch P, Smith D . Culture medium for enterobacteria. J Bacteriol. 1974; 119(3):736-47. PMC: 245675. DOI: 10.1128/jb.119.3.736-747.1974. View

11.

Hopfield J . Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity. Proc Natl Acad Sci U S A. 1974; 71(10):4135-9. PMC: 434344. DOI: 10.1073/pnas.71.10.4135. View

12.

Ninio J . Kinetic amplification of enzyme discrimination. Biochimie. 1975; 57(5):587-95. DOI: 10.1016/s0300-9084(75)80139-8. View

13.

Zengel J, Young R, Dennis P, Nomura M . Role of ribosomal protein S12 in peptide chain elongation: analysis of pleiotropic, streptomycin-resistant mutants of Escherichia coli. J Bacteriol. 1977; 129(3):1320-9. PMC: 235105. DOI: 10.1128/jb.129.3.1320-1329.1977. View

14.

Olsson M, ISAKSSON L . Analysis of rpsD mutations in Escherichia coli. I. Comparison of mutants with various alterations in ribosomal protein S4. Mol Gen Genet. 1979; 169(3):251-7. DOI: 10.1007/BF00382271. View

15.

Olsson M, ISAKSSON L . Analysis of rpsD mutations in Escherichia coli. IV. Accumulation of minor forms of protein S7(K) in ribosomes of rpsD mutant strains due to translational read-through. Mol Gen Genet. 1980; 177(3):485-91. DOI: 10.1007/BF00271488. View

16.

Andersson D, Bohman K, ISAKSSON L, Kurland C . Translation rates and misreading characteristics of rpsD mutants in Escherichia coli. Mol Gen Genet. 1982; 187(3):467-72. DOI: 10.1007/BF00332630. View

17.

Miller J, Albertini A . Effects of surrounding sequence on the suppression of nonsense codons. J Mol Biol. 1983; 164(1):59-71. DOI: 10.1016/0022-2836(83)90087-6. View

18.

Bossi L . Context effects: translation of UAG codon by suppressor tRNA is affected by the sequence following UAG in the message. J Mol Biol. 1983; 164(1):73-87. DOI: 10.1016/0022-2836(83)90088-8. View

19.

Steege D . A nucleotide change in the anticodon of an Escherichia coli serine transfer RNA results in supD-amber suppression. Nucleic Acids Res. 1983; 11(11):3823-32. PMC: 326005. DOI: 10.1093/nar/11.11.3823. View

20.

Petrullo L, Gallagher P, Elseviers D . The role of 2-methylthio-N6-isopentenyladenosine in readthrough and suppression of nonsense codons in Escherichia coli. Mol Gen Genet. 1983; 190(2):289-94. DOI: 10.1007/BF00330653. View