A Nucleotide Change in the Anticodon of an Escherichia Coli Serine Transfer RNA Results in SupD-amber Suppression

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 1983 Jun 11

PMID 6344015

Citations 15

Authors

D A Steege

Affiliations

Soon will be listed here.

Abstract

The tRNAs specified by the wild type and amber suppressor alleles of the Escherichia coli supD gene have been identified, and their primary structures determined. The sequences differ by a single nucleotide in the middle of the anticodon. A CUA anticodon allows the suppressor tRNA to read the UAG stop codon; the CGA anticodon in the minor serine tRNA species from which the suppressor is derived is specific for the serine codon UCG.

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