Mesenchymal Stem Cell Therapy for Ischemic Tissues

Overview

Journal Stem Cells Int

Publisher Wiley

Specialty Cell Biology

Date 2018 Nov 8

PMID 30402112

Citations 37

Authors

Kar Wey Yong

Jane Ru Choi

Mehdi Mohammadi

Alim P Mitha

Amir Sanati-Nezhad

Arindom Sen

Affiliations

Soon will be listed here.

Abstract

Ischemic diseases such as myocardial infarction, ischemic stroke, and critical limb ischemia are immense public health challenges. Current pharmacotherapy and surgical approaches are insufficient to completely heal ischemic diseases and are associated with a considerable risk of adverse effects. Alternatively, human mesenchymal stem cells (hMSCs) have been shown to exhibit immunomodulation, angiogenesis, and paracrine secretion of bioactive factors that can attenuate inflammation and promote tissue regeneration, making them a promising cell source for ischemic disease therapy. This review summarizes the pathogenesis of ischemic diseases, discusses the potential therapeutic effects and mechanisms of hMSCs for these diseases, and provides an overview of challenges of using hMSCs clinically for treating ischemic diseases.

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References

Perea-Gil I, Monguio-Tortajada M, Galvez-Monton C, Bayes-Genis A, Borras F, Roura S . Preclinical evaluation of the immunomodulatory properties of cardiac adipose tissue progenitor cells using umbilical cord blood mesenchymal stem cells: a direct comparative study. Biomed Res Int. 2015; 2015:439808. PMC: 4377370. DOI: 10.1155/2015/439808. View

Bago J, Soler-Botija C, Casani L, Aguilar E, Alieva M, Rubio N . Bioluminescence imaging of cardiomyogenic and vascular differentiation of cardiac and subcutaneous adipose tissue-derived progenitor cells in fibrin patches in a myocardium infarct model. Int J Cardiol. 2013; 169(4):288-95. DOI: 10.1016/j.ijcard.2013.09.013. View

Rehman J, Traktuev D, Li J, Merfeld-Clauss S, Temm-Grove C, Bovenkerk J . Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation. 2004; 109(10):1292-8. DOI: 10.1161/01.CIR.0000121425.42966.F1. View

Kim Y, Kim H, Cho H, Bae Y, Suh K, Jung J . Direct comparison of human mesenchymal stem cells derived from adipose tissues and bone marrow in mediating neovascularization in response to vascular ischemia. Cell Physiol Biochem. 2007; 20(6):867-76. DOI: 10.1159/000110447. View

Bayes-Genis A, Soler-Botija C, Farre J, Sepulveda P, Raya A, Roura S . Human progenitor cells derived from cardiac adipose tissue ameliorate myocardial infarction in rodents. J Mol Cell Cardiol. 2010; 49(5):771-80. DOI: 10.1016/j.yjmcc.2010.08.010. View

Regateiro F, Cobbold S, Waldmann H . CD73 and adenosine generation in the creation of regulatory microenvironments. Clin Exp Immunol. 2012; 171(1):1-7. PMC: 3530089. DOI: 10.1111/j.1365-2249.2012.04623.x. View

Onda T, Honmou O, Harada K, Houkin K, Hamada H, Kocsis J . Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified hMSCs after cerebral ischemia. J Cereb Blood Flow Metab. 2007; 28(2):329-40. PMC: 2605394. DOI: 10.1038/sj.jcbfm.9600527. View

Choi J, Pingguan-Murphy B, Wan Abas W, Yong K, Poon C, Noor Azmi M . In situ normoxia enhances survival and proliferation rate of human adipose tissue-derived stromal cells without increasing the risk of tumourigenesis. PLoS One. 2015; 10(1):e0115034. PMC: 4304807. DOI: 10.1371/journal.pone.0115034. View

Majka M, Sulkowski M, Badyra B, Musialek P . Concise Review: Mesenchymal Stem Cells in Cardiovascular Regeneration: Emerging Research Directions and Clinical Applications. Stem Cells Transl Med. 2017; 6(10):1859-1867. PMC: 6430161. DOI: 10.1002/sctm.16-0484. View

10.

Ma J, Sawai H, Ochi N, Matsuo Y, Xu D, Yasuda A . PTEN regulates angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells. Mol Cell Biochem. 2009; 331(1-2):161-71. DOI: 10.1007/s11010-009-0154-x. View

11.

von Wnuck Lipinski K, Keul P, Lucke S, Heusch G, Wohlschlaeger J, Baba H . Degraded collagen induces calpain-mediated apoptosis and destruction of the X-chromosome-linked inhibitor of apoptosis (xIAP) in human vascular smooth muscle cells. Cardiovasc Res. 2005; 69(3):697-705. DOI: 10.1016/j.cardiores.2005.08.005. View

12.

Hansson G, Libby P . The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol. 2006; 6(7):508-19. DOI: 10.1038/nri1882. View

13.

Yang F, Cho S, Son S, Bogatyrev S, Singh D, Green J . Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles. Proc Natl Acad Sci U S A. 2009; 107(8):3317-22. PMC: 2840438. DOI: 10.1073/pnas.0905432106. View

14.

Kim S, Lee D, Yu L, Zhang H, Kim C, Kim J . Mesenchymal stem cells overexpressing GCP-2 improve heart function through enhanced angiogenic properties in a myocardial infarction model. Cardiovasc Res. 2012; 95(4):495-506. DOI: 10.1093/cvr/cvs224. View

15.

Park I, Rhie J, Kim S . A novel three-dimensional adipose-derived stem cell cluster for vascular regeneration in ischemic tissue. Cytotherapy. 2013; 16(4):508-22. DOI: 10.1016/j.jcyt.2013.08.011. View

16.

Khurshid M, Mulet-Sierra A, Adesida A, Sen A . Osteoarthritic human chondrocytes proliferate in 3D co-culture with mesenchymal stem cells in suspension bioreactors. J Tissue Eng Regen Med. 2017; 12(3):e1418-e1432. PMC: 5770205. DOI: 10.1002/term.2531. View

17.

Chrobak K, Potter D, Tien J . Formation of perfused, functional microvascular tubes in vitro. Microvasc Res. 2006; 71(3):185-96. DOI: 10.1016/j.mvr.2006.02.005. View

18.

van der Worp H, Howells D, Sena E, Porritt M, Rewell S, OCollins V . Can animal models of disease reliably inform human studies?. PLoS Med. 2010; 7(3):e1000245. PMC: 2846855. DOI: 10.1371/journal.pmed.1000245. View

19.

Ankrum J, Ong J, Karp J . Mesenchymal stem cells: immune evasive, not immune privileged. Nat Biotechnol. 2014; 32(3):252-60. PMC: 4320647. DOI: 10.1038/nbt.2816. View

20.

Cai L, Johnstone B, Cook T, Tan J, Fishbein M, Chen P . IFATS collection: Human adipose tissue-derived stem cells induce angiogenesis and nerve sprouting following myocardial infarction, in conjunction with potent preservation of cardiac function. Stem Cells. 2008; 27(1):230-7. PMC: 2936459. DOI: 10.1634/stemcells.2008-0273. View