» Articles » PMID: 20361020

Can Animal Models of Disease Reliably Inform Human Studies?

Overview
Journal PLoS Med
Specialty General Medicine
Date 2010 Apr 3
PMID 20361020
Citations 550
Authors
Affiliations
Soon will be listed here.
Abstract

H. Bart van der Worp and colleagues discuss the controversies and possibilities of translating the results of animal experiments into human clinical trials.

Citing Articles

Lipidomics reveals cell specific changes during pluripotent differentiation to neural and mesodermal lineages.

Odenkirk M, Jostes H, Francis K, Baker E Mol Omics. 2025; .

PMID: 40078081 PMC: 11904469. DOI: 10.1039/d4mo00261j.


Nanoparticles for Thrombolytic Therapy in Ischemic Stroke: A Systematic Review and Meta-Analysis of Preclinical Studies.

Prego-Dominguez J, Laso-Garcia F, Palomar-Alonso N, Perez-Mato M, Lopez-Arias E, Dopico-Lopez A Pharmaceutics. 2025; 17(2).

PMID: 40006575 PMC: 11859612. DOI: 10.3390/pharmaceutics17020208.


Discordance between preclinical and clinical testing of Na V 1.7-selective inhibitors for pain.

Yang J, Xie Y, Smith R, Ratte S, Prescott S Pain. 2025; 166(3):481-501.

PMID: 39928833 PMC: 11808711. DOI: 10.1097/j.pain.0000000000003425.


Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading.

Nemec-Bakk A, Sridharan V, Willey J, Koturbash I, Williams D, Chesal M Life Sci Space Res (Amst). 2025; 44:38-46.

PMID: 39864910 PMC: 11770252. DOI: 10.1016/j.lssr.2024.12.001.


Nanocarrier-mediated cancer therapy with cisplatin: .

Ranasinghe R, Mathai M, Alshawsh M, Zulli A Heliyon. 2025; 10(7):e28171.

PMID: 39839154 PMC: 11747978. DOI: 10.1016/j.heliyon.2024.e28171.


References
1.
Scott S, Kranz J, Cole J, Lincecum J, Thompson K, Kelly N . Design, power, and interpretation of studies in the standard murine model of ALS. Amyotroph Lateral Scler. 2008; 9(1):4-15. DOI: 10.1080/17482960701856300. View

2.
Juni P, Altman D, Egger M . Systematic reviews in health care: Assessing the quality of controlled clinical trials. BMJ. 2001; 323(7303):42-6. PMC: 1120670. DOI: 10.1136/bmj.323.7303.42. View

3.
Sena E, van der Worp H, Howells D, Macleod M . How can we improve the pre-clinical development of drugs for stroke?. Trends Neurosci. 2007; 30(9):433-9. DOI: 10.1016/j.tins.2007.06.009. View

4.
Schulz K, Chalmers I, Hayes R, Altman D . Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA. 1995; 273(5):408-12. DOI: 10.1001/jama.273.5.408. View

5.
Schulz K, Grimes D . Allocation concealment in randomised trials: defending against deciphering. Lancet. 2002; 359(9306):614-8. DOI: 10.1016/S0140-6736(02)07750-4. View