Methods of Micropatterning and Manipulation of Cells for Biomedical Applications

Overview

Journal Micromachines (Basel)

Publisher MDPI

Date 2018 Nov 8

PMID 30400538

Citations 30

Authors

Adrian Martinez-Rivas

Genesis K Gonzalez-Quijano

Sergio Proa-Coronado

Childerick Severac

Etienne Dague

Affiliations

Soon will be listed here.

Abstract

Micropatterning and manipulation of mammalian and bacterial cells are important in biomedical studies to perform in vitro assays and to evaluate biochemical processes accurately, establishing the basis for implementing biomedical microelectromechanical systems (bioMEMS), point-of-care (POC) devices, or organs-on-chips (OOC), which impact on neurological, oncological, dermatologic, or tissue engineering issues as part of personalized medicine. Cell patterning represents a crucial step in fundamental and applied biological studies in vitro, hence today there are a myriad of materials and techniques that allow one to immobilize and manipulate cells, imitating the 3D in vivo milieu. This review focuses on current physical cell patterning, plus chemical and a combination of them both that utilizes different materials and cutting-edge micro-nanofabrication methodologies.

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