GammaH2AX and Cancer

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2008 Nov 14

PMID 19005492

Citations 839

Authors

William M Bonner

Christophe E Redon

Jennifer S Dickey

Asako J Nakamura

Olga A Sedelnikova

Stephanie Solier

Yves Pommier

Affiliations

Soon will be listed here.

Abstract

Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus (producing gammaH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may lead to cancer but, paradoxically, are also used to kill cancer cells. Using gammaH2AX detection to determine the extent of DSB induction may help to detect precancerous cells, to stage cancers, to monitor the effectiveness of cancer therapies and to develop novel anticancer drugs.

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