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GammaH2AX and Cancer

Overview
Journal Nat Rev Cancer
Specialty Oncology
Date 2008 Nov 14
PMID 19005492
Citations 839
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Abstract

Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus (producing gammaH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may lead to cancer but, paradoxically, are also used to kill cancer cells. Using gammaH2AX detection to determine the extent of DSB induction may help to detect precancerous cells, to stage cancers, to monitor the effectiveness of cancer therapies and to develop novel anticancer drugs.

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