Self-Assembled Aptamer-Grafted Hyperbranched Polymer Nanocarrier for Targeted and Photoresponsive Drug Delivery

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2018 Nov 3

PMID 30387923

Citations 39

Authors

Lu Yang

Hao Sun

Yuan Liu

Weijia Hou

Yu Yang

Ren Cai

Cheng Cui

Penghui Zhang

Xiaoshu Pan

Xiaowei Li

Long Li

Brent S Sumerlin

Weihong Tan

Affiliations

Soon will be listed here.

Abstract

Photoresponsive materials are emerging as ideal carriers for precisely controlled drug delivery owing to their high spatiotemporal selectivity. However, drawbacks such as slow release kinetics, inherent toxicity, and lack of targeting ability hinder their translation into clinical use. We constructed a new DNA aptamer-grafted photoresponsive hyperbranched polymer, which can self-assemble into nanoparticles, thereby achieving biocompatibility and target specificity, as well as light-controllable release behavior. Upon UV-irradiation, rapid release induced by disassembly was observed for Nile Red-loaded nanoparticles. Further in vitro cell studies confirmed this delivery system's specific binding and internalization performance arising from the DNA aptamer corona. The DOX-loaded nanoassembly exhibited selective phototriggered cytotoxicity towards cancer cells, indicating its promising therapeutic effect as a smart drug delivery system.

Citing Articles

Polymeric Nanoparticles for Drug Delivery.

Beach M, Nayanathara U, Gao Y, Zhang C, Xiong Y, Wang Y Chem Rev. 2024; 124(9):5505-5616.

PMID: 38626459 PMC: 11086401. DOI: 10.1021/acs.chemrev.3c00705.

Aptamer-Based Smart Targeting and Spatial Trigger-Response Drug-Delivery Systems for Anticancer Therapy.

Park D, Lee S, Park J Biomedicines. 2024; 12(1).

PMID: 38255292 PMC: 10813750. DOI: 10.3390/biomedicines12010187.

Aptamer-based self-assembled nanomicelle enables efficient and targeted drug delivery.

Chen G, Mao D, Wang X, Chen J, Gu C, Huang S J Nanobiotechnology. 2023; 21(1):415.

PMID: 37946192 PMC: 10634091. DOI: 10.1186/s12951-023-02164-y.

Aptamer-engineered (nano)materials for theranostic applications.

Rabiee N, Chen S, Ahmadi S, Veedu R Theranostics. 2023; 13(15):5183-5206.

PMID: 37908725 PMC: 10614690. DOI: 10.7150/thno.85419.

Hyperbranched Polymers: Recent Advances in Photodynamic Therapy against Cancer.

Chen J, Zhang Y Pharmaceutics. 2023; 15(9).

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