Aptamer-engineered (nano)materials for Theranostic Applications

Overview

Journal Theranostics

Date 2023 Nov 1

PMID 37908725

Authors

Navid Rabiee

Suxiang Chen

Sepideh Ahmadi

Rakesh N Veedu

Affiliations

Soon will be listed here.

Abstract

A diverse array of organic and inorganic materials, including nanomaterials, has been extensively employed in multifunctional biomedical applications. These applications encompass drug/gene delivery, tissue engineering, biosensors, photodynamic and photothermal therapy, and combinatorial sciences. Surface and bulk engineering of these materials, by incorporating biomolecules and aptamers, offers several advantages such as decreased cytotoxicity, improved stability, enhanced selectivity/sensitivity toward specific targets, and expanded multifunctional capabilities. In this comprehensive review, we specifically focus on aptamer-modified engineered materials for diverse biomedical applications. We delve into their mechanisms, advantages, and challenges, and provide an in-depth analysis of relevant literature references. This critical evaluation aims to enhance the scientific community's understanding of this field and inspire new ideas for future research endeavors.

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References

Zhu G, Hu R, Zhao Z, Chen Z, Zhang X, Tan W . Noncanonical self-assembly of multifunctional DNA nanoflowers for biomedical applications. J Am Chem Soc. 2013; 135(44):16438-45. PMC: 3855874. DOI: 10.1021/ja406115e. View

Chu T, Marks 3rd J, Lavery L, Faulkner S, Rosenblum M, Ellington A . Aptamer:toxin conjugates that specifically target prostate tumor cells. Cancer Res. 2006; 66(12):5989-92. DOI: 10.1158/0008-5472.CAN-05-4583. View

Sargazi S, Er S, Mobashar A, Gelen S, Rahdar A, Ebrahimi N . Aptamer-conjugated carbon-based nanomaterials for cancer and bacteria theranostics: A review. Chem Biol Interact. 2022; 361:109964. DOI: 10.1016/j.cbi.2022.109964. View

Liu J, Cui M, Niu L, Zhou H, Zhang S . Enhanced Peroxidase-Like Properties of Graphene-Hemin-Composite Decorated with Au Nanoflowers as Electrochemical Aptamer Biosensor for the Detection of K562 Leukemia Cancer Cells. Chemistry. 2016; 22(50):18001-18008. DOI: 10.1002/chem.201604354. View

Ahmadi S, Rabiee N, Bagherzadeh M, Elmi F, Fatahi Y, Farjadian F . Stimulus-Responsive Sequential Release Systems for Drug and Gene Delivery. Nano Today. 2020; 34. PMC: 7416836. DOI: 10.1016/j.nantod.2020.100914. View

Rabiee N, Bagherzadeh M, Haris M, Ghadiri A, Moghaddam F, Fatahi Y . Polymer-Coated NH-UiO-66 for the Codelivery of DOX/pCRISPR. ACS Appl Mater Interfaces. 2021; 13(9):10796-10811. DOI: 10.1021/acsami.1c01460. View

Duong V, Nguyen T, Maeng H . Recent Advances in Intranasal Liposomes for Drug, Gene, and Vaccine Delivery. Pharmaceutics. 2023; 15(1). PMC: 9865923. DOI: 10.3390/pharmaceutics15010207. View

Li J, Mo L, Lu C, Fu T, Yang H, Tan W . Functional nucleic acid-based hydrogels for bioanalytical and biomedical applications. Chem Soc Rev. 2016; 45(5):1410-31. PMC: 4775362. DOI: 10.1039/c5cs00586h. View

Song P, Ye D, Zuo X, Li J, Wang J, Liu H . DNA Hydrogel with Aptamer-Toehold-Based Recognition, Cloaking, and Decloaking of Circulating Tumor Cells for Live Cell Analysis. Nano Lett. 2017; 17(9):5193-5198. DOI: 10.1021/acs.nanolett.7b01006. View

10.

Zhang H, Zhao X, Chen L, Yang C, Yan X . Dendrimer grafted persistent luminescent nanoplatform for aptamer guided tumor imaging and acid-responsive drug delivery. Talanta. 2020; 219:121209. DOI: 10.1016/j.talanta.2020.121209. View

11.

Li J, Qiu L, Xie S, Zhang J, Zhang L, Liu H . Engineering a customized nanodrug delivery system at the cellular level for targeted cancer therapy. Sci China Chem. 2018; 61(4):497-504. PMC: 6157601. DOI: 10.1007/s11426-017-9176-3. View

12.

Azhdarzadeh M, Atyabi F, Saei A, Shiri Varnamkhasti B, Omidi Y, Fateh M . Theranostic MUC-1 aptamer targeted gold coated superparamagnetic iron oxide nanoparticles for magnetic resonance imaging and photothermal therapy of colon cancer. Colloids Surf B Biointerfaces. 2016; 143:224-232. DOI: 10.1016/j.colsurfb.2016.02.058. View

13.

Pan Q, Nie C, Hu Y, Yi J, Liu C, Zhang J . Aptamer-Functionalized DNA Origami for Targeted Codelivery of Antisense Oligonucleotides and Doxorubicin to Enhance Therapy in Drug-Resistant Cancer Cells. ACS Appl Mater Interfaces. 2019; 12(1):400-409. DOI: 10.1021/acsami.9b20707. View

14.

Yang L, Sun H, Liu Y, Hou W, Yang Y, Cai R . Self-Assembled Aptamer-Grafted Hyperbranched Polymer Nanocarrier for Targeted and Photoresponsive Drug Delivery. Angew Chem Int Ed Engl. 2018; 57(52):17048-17052. PMC: 6442708. DOI: 10.1002/anie.201809753. View

15.

Ning W, Di Z, Yu Y, Zeng P, Di C, Chen D . Imparting Designer Biorecognition Functionality to Metal-Organic Frameworks by a DNA-Mediated Surface Engineering Strategy. Small. 2018; 14(11):e1703812. DOI: 10.1002/smll.201703812. View

16.

Mohammadzadeh P, Cohan R, Ghoreishi S, Bitarafan-Rajabi A, Shafiee Ardestani M . AS1411 Aptamer-Anionic Linear Globular Dendrimer G2-Iohexol Selective Nano-Theranostics. Sci Rep. 2017; 7(1):11832. PMC: 5605695. DOI: 10.1038/s41598-017-12150-8. View

17.

Zhao N, Suzuki A, Zhang X, Shi P, Abune L, Coyne J . Dual Aptamer-Functionalized in Situ Injectable Fibrin Hydrogel for Promotion of Angiogenesis via Codelivery of Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor-BB. ACS Appl Mater Interfaces. 2019; 11(20):18123-18132. PMC: 6542593. DOI: 10.1021/acsami.9b02462. View

18.

Alibolandi M, Hoseini F, Mohammadi M, Ramezani P, Einafshar E, Taghdisi S . Curcumin-entrapped MUC-1 aptamer targeted dendrimer-gold hybrid nanostructure as a theranostic system for colon adenocarcinoma. Int J Pharm. 2018; 549(1-2):67-75. DOI: 10.1016/j.ijpharm.2018.07.052. View

19.

Herrera V, Colby A, Ruiz-Opazo N, Coleman D, Grinstaff M . Nucleic acid nanomedicines in Phase II/III clinical trials: translation of nucleic acid therapies for reprogramming cells. Nanomedicine (Lond). 2018; 13(16):2083-2098. PMC: 6219437. DOI: 10.2217/nnm-2018-0122. View

20.

Shangguan D, Li Y, Tang Z, Cao Z, Chen H, Mallikaratchy P . Aptamers evolved from live cells as effective molecular probes for cancer study. Proc Natl Acad Sci U S A. 2006; 103(32):11838-43. PMC: 1567664. DOI: 10.1073/pnas.0602615103. View