MicroRNAs As Biomarkers of B-cell Lymphoma

Overview

Journal Biomark Insights

Publisher Sage Publications

Date 2018 Oct 24

PMID 30349178

Citations 17

Authors

Carla Sole

Esther Arnaiz

Charles H Lawrie

Affiliations

Soon will be listed here.

Abstract

B-cell lymphomas represent a diverse group of neoplasms classified primarily by histopatholgy and are often challenging to accurately diagnose. Despite having been recognized less than 20 years ago, microRNAs (miRNAs) have emerged as one of the most promising class of cancer molecular biomarkers and are particularly attractive as they can be readily detected in formalin-fixed paraffin-embedded biopsy material and biological fluids such as blood. Many of the identified B-cell lymphoma miRNA biomarkers also play crucial regulatory roles in normal B-cell development. Below we consider the identity, function, and biomarker potential of miRNAs in B-cell lymphoma and most importantly the barriers that remain to be overcome if they are really to become part of routine clinical practice.

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