Disassembly of Dying Cells in Diverse Organisms

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2018 Oct 15

PMID 30317529

Citations 7

Authors

Rochelle Tixeira

Ivan K H Poon

Affiliations

Soon will be listed here.

Abstract

Programmed cell death (PCD) is a conserved phenomenon in multicellular organisms required to maintain homeostasis. Among the regulated cell death pathways, apoptosis is a well-described form of PCD in mammalian cells. One of the characteristic features of apoptosis is the change in cellular morphology, often leading to the fragmentation of the cell into smaller membrane-bound vesicles through a process called apoptotic cell disassembly. Interestingly, some of these morphological changes and cell disassembly are also noted in cells of other organisms including plants, fungi and protists while undergoing 'apoptosis-like PCD'. This review will describe morphologic features leading to apoptotic cell disassembly, as well as its regulation and function in mammalian cells. The occurrence of cell disassembly during cell death in other organisms namely zebrafish, fly and worm, as well as in other eukaryotic cells will also be discussed.

Citing Articles

Extracellular vesicles and nanoparticles at a glance.

Jeppesen D, Zhang Q, Coffey R J Cell Sci. 2024; 137(23).

PMID: 39641198 PMC: 11658686. DOI: 10.1242/jcs.260201.

Axonal spheroids are regulated by Schwann cells after peripheral nerve injury.

Hunter-Chang S, Kim-Aun C, Karim H, Jones M, Vegiraju T, Stepanova E bioRxiv. 2024; .

PMID: 39574635 PMC: 11581001. DOI: 10.1101/2024.11.08.622649.

The Neuroprotection Effects of Exosome in Central Nervous System Injuries: a New Target for Therapeutic Intervention.

Zhang L, Mao L, Wang H Mol Neurobiol. 2022; 59(12):7152-7169.

PMID: 36103108 DOI: 10.1007/s12035-022-03028-6.

Extracellular Vesicles Physiological Role and the Particular Case of Disease-Spreading Mechanisms in Polyglutamine Diseases.

Moreira R, Mendonca L, de Almeida L Int J Mol Sci. 2021; 22(22).

PMID: 34830171 PMC: 8621536. DOI: 10.3390/ijms222212288.

Apoptosis is not conserved in plants as revealed by critical examination of a model for plant apoptosis-like cell death.

Minina E, Dauphinee A, Ballhaus F, Gogvadze V, Smertenko A, Bozhkov P BMC Biol. 2021; 19(1):100.

PMID: 33980238 PMC: 8117276. DOI: 10.1186/s12915-021-01018-z.

References

Meslin B, Barnadas C, Boni V, Latour C, de Monbrison F, Kaiser K . Features of apoptosis in Plasmodium falciparum erythrocytic stage through a putative role of PfMCA1 metacaspase-like protein. J Infect Dis. 2007; 195(12):1852-9. DOI: 10.1086/518253. View

Carmona-Gutierrez D, Frohlich K, Kroemer G, Madeo F . Metacaspases are caspases. Doubt no more. Cell Death Differ. 2010; 17(3):377-8. DOI: 10.1038/cdd.2009.198. View

Eimon P, Ashkenazi A . The zebrafish as a model organism for the study of apoptosis. Apoptosis. 2009; 15(3):331-49. DOI: 10.1007/s10495-009-0432-9. View

White K, Grether M, Abrams J, Young L, Farrell K, Steller H . Genetic control of programmed cell death in Drosophila. Science. 1994; 264(5159):677-83. DOI: 10.1126/science.8171319. View

Atkin-Smith G, Poon I . Disassembly of the Dying: Mechanisms and Functions. Trends Cell Biol. 2016; 27(2):151-162. DOI: 10.1016/j.tcb.2016.08.011. View

Duszenko M, Figarella K, MacLeod E, Welburn S . Death of a trypanosome: a selfish altruism. Trends Parasitol. 2006; 22(11):536-42. DOI: 10.1016/j.pt.2006.08.010. View

Sherrard K, Robin F, Lemaire P, Munro E . Sequential activation of apical and basolateral contractility drives ascidian endoderm invagination. Curr Biol. 2010; 20(17):1499-510. PMC: 4088275. DOI: 10.1016/j.cub.2010.06.075. View

Sulston J, Horvitz H . Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev Biol. 1977; 56(1):110-56. DOI: 10.1016/0012-1606(77)90158-0. View

Kurtenbach S, Prochnow N, Kurtenbach S, Klooster J, Zoidl C, Dermietzel R . Pannexin1 channel proteins in the zebrafish retina have shared and unique properties. PLoS One. 2013; 8(10):e77722. PMC: 3808535. DOI: 10.1371/journal.pone.0077722. View

10.

Welburn S, Dale C, Ellis D, Beecroft R, Pearson T . Apoptosis in procyclic Trypanosoma brucei rhodesiense in vitro. Cell Death Differ. 1996; 3(2):229-36. View

11.

Dorstyn L, Colussi P, Quinn L, Richardson H, Kumar S . DRONC, an ecdysone-inducible Drosophila caspase. Proc Natl Acad Sci U S A. 1999; 96(8):4307-12. PMC: 16328. DOI: 10.1073/pnas.96.8.4307. View

12.

Mandal D, Moitra P, Saha S, Basu J . Caspase 3 regulates phosphatidylserine externalization and phagocytosis of oxidatively stressed erythrocytes. FEBS Lett. 2002; 513(2-3):184-8. DOI: 10.1016/s0014-5793(02)02294-9. View

13.

Degterev A, Boyce M, Yuan J . A decade of caspases. Oncogene. 2003; 22(53):8543-67. DOI: 10.1038/sj.onc.1207107. View

14.

Bakkers J . Zebrafish as a model to study cardiac development and human cardiac disease. Cardiovasc Res. 2011; 91(2):279-88. PMC: 3125074. DOI: 10.1093/cvr/cvr098. View

15.

Abrams J, White K, Fessler L, Steller H . Programmed cell death during Drosophila embryogenesis. Development. 1993; 117(1):29-43. DOI: 10.1242/dev.117.1.29. View

16.

Qadri S, Bissinger R, Solh Z, Oldenborg P . Eryptosis in health and disease: A paradigm shift towards understanding the (patho)physiological implications of programmed cell death of erythrocytes. Blood Rev. 2017; 31(6):349-361. DOI: 10.1016/j.blre.2017.06.001. View

17.

Oropesa-Avila M, Cruz-Ojeda P, Porcuna J, Villanueva-Paz M, Fernandez-Vega A, de la Mata M . Two coffins and a funeral: early or late caspase activation determines two types of apoptosis induced by DNA damaging agents. Apoptosis. 2016; 22(3):421-436. DOI: 10.1007/s10495-016-1337-z. View

18.

Chekeni F, Elliott M, Sandilos J, Walk S, Kinchen J, Lazarowski E . Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. Nature. 2010; 467(7317):863-7. PMC: 3006164. DOI: 10.1038/nature09413. View

19.

Wang Y, Gao W, Shi X, Ding J, Liu W, He H . Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature. 2017; 547(7661):99-103. DOI: 10.1038/nature22393. View

20.

Lang E, Qadri S, Lang F . Killing me softly - suicidal erythrocyte death. Int J Biochem Cell Biol. 2012; 44(8):1236-43. DOI: 10.1016/j.biocel.2012.04.019. View