The MA‑methylase Complex and MRNA Export

Overview

Journal Biochim Biophys Acta Gene Regul Mech

Publisher Elsevier

Specialties Biochemistry
Biophysics
Genetics
Molecular Biology

Date 2018 Oct 6

PMID 30290229

Citations 29

Authors

Simon Lesbirel

Stuart A Wilson

Affiliations

Soon will be listed here.

Abstract

During synthesis, mRNA undergoes a number of modifications such as capping, splicing and polyadenylation. These processes are coupled with the orderly deposition of the TREX complex on the mRNA and subsequent recruitment of the NXF1-P15 heterodimer which stimulates the nuclear export of mature mRNAs. mRNAs also undergo a number of internal modifications, the most common of which is the N‑methyladenosine (mA) modification. In this review we discuss the recent evidence of coupling between the mA modification, RNA processing and export.

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-6-methyladenosine (m6A) promotes the nuclear retention of mRNAs with intact 5' splice site motifs.

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Nuclear mRNA export.

Chen S, Jiang Q, Fan J, Cheng H Acta Biochim Biophys Sin (Shanghai). 2024; 57(1):84-100.

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