Cancer Stem Cells in Progression of Colorectal Cancer

Overview

Journal Oncotarget

Specialty Oncology

Date 2018 Oct 4

PMID 30279970

Citations 128

Authors

Yujuan Zhou

Longzheng Xia

Heran Wang

Linda Oyang

Min Su

Qiang Liu

Jingguan Lin

Shiming Tan

Yutong Tian

Qianjin Liao

Deliang Cao

Affiliations

Soon will be listed here.

Abstract

Colorectal cancer is one of the most common cancers worldwide with high mortality. Distant metastasis and relapse are major causes of patient death. Cancer stem cells (CSCs) play a critical role in the metastasis and relapse of colorectal cancer. CSCs are a subpopulation of cancer cells with unique properties of self-renewal, infinite division and multi-directional differentiation potential. Colorectal CSCs are defined with a group of cell surface markers, such as CD44, CD133, CD24, EpCAM, LGR5 and ALDH. They are highly tumorigenic, chemoresistant and radioresistant and thus are critical in the metastasis and recurrence of colorectal cancer and disease-free survival. This review article updates the colorectal CSCs with a focus on their role in tumor initiation, progression, drug resistance and tumor relapse.

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