Oncogenic Roles of EMT-inducing Transcription Factors

Overview

Journal Nat Cell Biol

Specialty Cell Biology

Date 2014 May 31

PMID 24875735

Citations 573

Authors

Alain Puisieux

Thomas Brabletz

Julie Caramel

Affiliations

Soon will be listed here.

Abstract

The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they encounter during tumour development. Aberrant reactivation of epithelial-mesenchymal transition (EMT), an essential embryonic process, can promote cancer cell plasticity and fuel both tumour initiation and metastatic spread. Here we discuss the roles of EMT-inducing transcription factors in creating a pro-tumorigenic setting characterized by an intrinsic ability to withstand oncogenic insults through the mitigation of p53-dependent oncosuppressive functions and the gain of stemness-related properties.

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