Abrogation of Resistance to Severe Mousepox in C57BL/6 Mice Infected with LP-BM5 Murine Leukemia Viruses

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1987 Feb 1

PMID 3027368

Citations 36

Authors

R M Buller

R A Yetter

T N Fredrickson

H C Morse 3rd

Affiliations

Soon will be listed here.

Abstract

Strain C57BL/6 (B6) mice infected with LP-BM5 murine leukemia virus (MuLV) develop a disease which combines abnormal lymphoproliferation with profound immunosuppression and has many features in common with human acquired immunodeficiency syndrome induced by HTLV-III/LAV retroviruses. To determine whether this LP-BM5 MuLV infection would affect the innate resistance of B6 mice to a naturally occurring, highly virulent murine pathogen, mice were exposed to ectromelia virus at various times after treatment with LP-BM5 viruses. At week 4 after infection with LP-BM5, mice challenged with ectromelia virus were unable to generate a humoral immune response to this virus, and between weeks 8 and 10 after infection, challenged mice lost the ability to generate an ectromelia virus-specific cytotoxic-T-cell response. Loss of the cellular immune responses to ectromelia virus was associated with an increased susceptibility to the lethal effects of the virus.

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