CD40-associated TRAF 6 Signaling is Required for Disease Induction in a Retrovirus-induced Murine Immunodeficiency

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2004 May 14

PMID 15141004

Citations 8

Authors

Kathy A Green

Cory L Ahonen

W James Cook

William R Green

Affiliations

Soon will be listed here.

Abstract

LP-BM5 retrovirus-infected C57BL/6 mice develop splenomegaly, lymphadenopathy, hypergammaglobulinemia, and immunodeficiency; thus, this disease has been named mouse AIDS. In this syndrome, CD154/CD40 interactions are required for but do not mediate disease by upregulation of CD80 or CD86. We report here that there is nonetheless a necessity for CD40 signaling competence, specifically an intact tumor necrosis factor receptor-associated factor 6 (TRAF 6) binding site.

Citing Articles

Myeloid-derived suppressor cells in murine AIDS inhibit B-cell responses in part via soluble mediators including reactive oxygen and nitrogen species, and TGF-β.

Rastad J, Green W Virology. 2016; 499:9-22.

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Subpopulations of M-MDSCs from mice infected by an immunodeficiency-causing retrovirus and their differential suppression of T- vs B-cell responses.

OConnor M, Fu W, Green K, Green W Virology. 2015; 485:263-73.

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Myeloid-derived suppressor cells in murine retrovirus-induced AIDS inhibit T- and B-cell responses in vitro that are used to define the immunodeficiency.

Green K, Cook W, Green W J Virol. 2012; 87(4):2058-71.

PMID: 23221564 PMC: 3571497. DOI: 10.1128/JVI.01547-12.

Immunotherapy of murine retrovirus-induced acquired immunodeficiency by CD4 T regulatory cell depletion and PD-1 blockade.

Li W, Green W J Virol. 2011; 85(24):13342-53.

PMID: 21917983 PMC: 3233148. DOI: 10.1128/JVI.00120-11.

The programmed death-1 and interleukin-10 pathways play a down-modulatory role in LP-BM5 retrovirus-induced murine immunodeficiency syndrome.

Green K, Okazaki T, Honjo T, Cook W, Green W J Virol. 2007; 82(5):2456-69.

PMID: 18094175 PMC: 2258922. DOI: 10.1128/JVI.01665-07.

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