Modulation by Phorbol Myristate Acetate of Arachidonic Acid Release and Leukotriene Synthesis by Human Polymorphonuclear Leukocytes Stimulated with A23187

Overview

Journal Biochem Biophys Res Commun

Publisher Elsevier

Specialty Biochemistry

Date 1986 Dec 15

PMID 3026382

Citations 18

Authors

S R McColl

N P Hurst

L G Cleland

Affiliations

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Abstract

Phorbol myristate acetate augmented the release of 3H-AA and the synthesis of leukotriene B4 and 5-hydroxyeicosatetraenoic acid by human polymorphonuclear leukocytes stimulated by A23187. PMA alone had no effect. Enhancement of the response to A23187 was not seen when the inactive phorbol ester 4-alpha phorbol didecanoate was added with A23187. These data are consistent with the hypothesis that activation of protein kinase C enhances AA release and metabolism in stimulated polymorphonuclear leukocytes.

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