Chemotactic Peptide-induced Arachidonic Acid Mobilization in Human Polymorphonuclear Leukocytes

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1988 Nov 1

PMID 3142268

Citations 3

Authors

G M Galbraith

Affiliations

Soon will be listed here.

Abstract

Human polymorphonuclear leukocytes prelabeled with tritiated arachidonic acid liberated radiolabeled products when exposed to the chemotactic peptide fMet-Leu-Phe. The effect was enhanced in the presence of phorbol-12-myristate 13-acetate or 1-oleoyl-2-acetyl glycerol; these agents activate phospholipid- and Ca2+-dependent protein kinase C. In contrast, arachidonic acid mobilization was suppressed by two compounds known to inhibit protein kinase C activity: polymyxin B and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine. These results suggest that protein kinase C was involved in arachidonic acid mobilization in leukocytes stimulated with chemotactic peptide.

Citing Articles

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