Article: Cell fate in colon cancer stem cells: To GLI or not to GLI?

Colon cancer is a heterogeneous tumor driven by subpopulations of cancer stem cells (CSCs). We recently used patient-derived organoids (PDOs) to demonstrate that CSC survival is regulated by autocrine non-canonical Hedgehog signaling, which acts as a positive regulator of Wnt signaling to block CSC differentiation.

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Cell Fate in Colon Cancer Stem Cells: To GLI or Not to GLI?